L-N6-(1-Iminoethyl)lysine dihydrochloride

Base Information

• Chemical Name: L-N6-(1-Iminoethyl)lysine dihydrochloride
• CAS No.: 159190-45-1
• Molecular Formula: C8H19Cl2N3O2
• Molecular Weight: 260.16
• European Community (EC) Number: 803-059-8
• UNII: 8BL5V0T01Y
• DSSTox Substance ID: DTXSID3040562
• Wikidata: Q27132937
• ChEMBL ID: CHEMBL1744034
• Mol file: 159190-45-1.mol

Synonyms:L-N6-(1-Iminoethyl)lysine dihydrochloride;159190-45-1;N-iminoethyl-L-lysine dihydrochloride;L-NIL (dihydrochloride);8BL5V0T01Y;UNII-8BL5V0T01Y;CHEMBL1744034;CHEBI:63964;L-Lysine, N6-(1-iminoethyl)-, dihydrochloride;L-Lysine, N6-(1-iminoethyl)-, hydrochloride (1:2);(2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochloride;L-NIL (hydrochloride);L-NIL.2HCl;SCHEMBL677147;DTXSID3040562;-Acetimidoyllysine dihydrochloride;BCP16613;AKOS025294562;N(6)-acetimidoyllysine dihydrochloride;N(6)-acetimidoyl-L-lysine hydrochloride;N6-ethanimidoyl-L-lysine dihydrochloride;HY-12118;N(6)-acetimidoyl-L-lysine dihydrochloride;N(6)-ethanimidoyl-L-lysine dihydrochloride;n6-(1-iminoethyl)-l-lysine dihydrochloride;CS-0003090;L-N(6)-(1-iminoethyl)lysine dihydrochloride;N6-(1-iminoethyl)-L-lysine, dihydrochloride;L-Lysine,n6-(1-iminoethyl)-,hydrochloride(1:1);J-009575;Q27132937;(S)-6-Acetimidamido-2-aminohexanoic acid dihydrochloride;(1-{[(5S)-5-ammonio-5-carboxypentyl]amino}ethylidene)ammonium dichloride

Chemical Property of L-N6-(1-Iminoethyl)lysine dihydrochloride

Chemical Property:

• Boiling Point: 369 °C at 760 mmHg
• Flash Point: 177 °C
• PSA: 99.20000
• LogP: 2.95030
• Storage Temp.: -20°C
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 259.0854322
• Heavy Atom Count: 15
• Complexity: 192

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-N6-(1-Iminoethyl)lysine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NCCCCC(C(=O)O)N)N.Cl.Cl
• Isomeric SMILES: CC(=NCCCC[C@@H](C(=O)O)N)N.Cl.Cl
• Description: L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
• Uses: L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor: to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murineto study its effects on leptin-induced inflammation in hepatocytes to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)