(R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE

Base Information

• Chemical Name: (R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE
• CAS No.: 158923-11-6
• Molecular Formula: C32H52 Fe P2
• Molecular Weight: 542.464
• Hs Code.: 29319090
• Mol file: 158923-11-6.mol

Synonyms:Ferrocene,1-[1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(dicyclohexylphosphino)-,[R-(R*,R*)]-;(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine;[(R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl]di-tert-butylphosphine

Chemical Property of (R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE

Chemical Property:

• PSA: 27.18000
• LogP: 10.06670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-[(SP)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: It may be used as a ligand in the palladium catalyzed hetero cross-coupling between aryl bromides/aryl triflates with potassium thioacetate to form S-aryl thioacetates.

Technology Process of (R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE

There total 1 articles about (R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R,R(Fc))-1-(diphenylphosphino-κP)-2-[1-(di-tert-butylphosphino-κP)ethyl]ferrocene hexahydridodiboron → (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine (158923-11-6)

Guidance literature:

In further solvent(s); under Ar; degassed suspn. of Fe complex in morpholine heated to 100°C for 3 h; cooled; solvent removed under reduced pressure; extd. (Et2O); combined org. layers washed (aq. citric acid, brine); dried (MgSO4); solvent removed on rotary evaporator; purified by chromy. under inert conditions (aluminum oxide 90, petroleum ether-Et2O 1:1);

DOI:10.1021/om100843u

Reference yield: 77.0%

(R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine (158923-11-6,928342-16-9,950982-61-3,950982-71-5,1246841-00-8) + di(2-(2′-amino-1,1′-biphenyl))palladium(II) methanesulfonate dimer → C45H65FeNO3P2PdS

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2015.03.080

Reference yield: 74.0%

(R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine (158923-11-6,928342-16-9,950982-61-3,950982-71-5,1246841-00-8) + (P(o-tol)3)2Pd2(C6H4CH3-4)2Br2 (157076-55-6) → [Pd(1-dicyclohexylphosphino-2-di-tert-butylphosphinoethylferrocene)(p-tolyl)Br] (1154042-81-5)

Guidance literature:

In tetrahydrofuran; 2 equiv of phosphine, THF, room temp.;

Downstream raw materials:

[Pd(1-dicyclohexylphosphino-2-di-tert-butylphosphinoethylferrocene)(P(o-tolyl)3)]

(C₅H₅)Fe(C₅H₃(CH(CH₃)P(C(CH₃)3)2)P(C₆H₁₁)2)PtCl₂

[Pd(1-dicyclohexylphosphino-2-di-tert-butylphosphinoethylferrocene)(H)(2-propanethiolate)]

[Pd(1-dicyclohexylphosphino-2-di-tert-butylphosphinoethylferrocene)(p-tolyl)Br]

Refernces