Technology Process of 4,4'-bis(2-((2S)-1-(N-(methoxycarbonyl)-L-valyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-2-biphenylcarboxylic acid
There total 3 articles about 4,4'-bis(2-((2S)-1-(N-(methoxycarbonyl)-L-valyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-2-biphenylcarboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / palladium 10% on activated carbon / methanol / 5 h
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 5.5 h
3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
With
hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; HATU;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane; dichloromethane / 5.5 h
2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
With
hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
