(S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID

Base Information

• Chemical Name: (S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID
• CAS No.: 154006-66-3
• Molecular Formula: C8H8 F N O2
• Molecular Weight: 169.155
• Hs Code.: 2922498590
• Mol file: 154006-66-3.mol

Synonyms:Benzeneaceticacid, a-amino-3-fluoro-, (S)-

Chemical Property of (S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID

Chemical Property:

• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 286.5°Cat760mmHg
• Flash Point: 127.1°C
• PSA: 63.32000
• Density: 1.347g/cm³
• LogP: 1.61040

Purity/Quality:

98%min ^*data from raw suppliers

(S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID

There total 1 articles about (S)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (S)-2-amino-2-(3-fluorophenyl)acetic acid (154006-66-3)

Guidance literature:

aus entspr. Formamid;

Reference yield: 87.95%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-2-(3-fluorophenyl)acetic acid (154006-66-3) → (S)-2-((tert-butoxycarbonyl)amino)-2-(3-fluorophenyl)acetic acid (1228542-64-0)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

(S)-2-amino-2-(3-fluorophenyl)acetic acid (154006-66-3) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → C10H13FN2O2

Guidance literature:

(S)-2-amino-2-(3-fluorophenyl)acetic acid; N,O-dimethylhydroxylamine*hydrochloride; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In acetonitrile; at 0 ℃; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm4012643

Downstream raw materials:

(3S,6S)-6-(3-fluorophenyl)-4-(5-(4-fluorophenyl)isoxazole-3-carbonyl)-3-isobutylpiperazin-2-one

(3S,6S)-3-isobutyl-6-p-tolyl-piperazin-2-one

(S)-2-((tert-butoxycarbonyl)amino)-2-(3-fluorophenyl)acetic acid