PYROXSULAM

Base Information

• Chemical Name: PYROXSULAM
• CAS No.: 422556-08-9
• Molecular Formula: C14H13 F3 N6 O5 S
• Molecular Weight: 434.356
• Mol file: 422556-08-9.mol

Synonyms:DE 742;Pyroxsulam

Chemical Property of PYROXSULAM

Chemical Property:

• Refractive Index: 1.633
• Boiling Point: °Cat760mmHg
• PKA: 1.92±0.30(Predicted)
• Flash Point: °C
• PSA: 138.21000
• Density: 1.68g/cm³
• LogP: 2.51850
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

PYROXSULAM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyroxsulam is a herbicide containing auxin hormone and two acetolactate synthase inhibitors for controlling weeds.

Technology Process of PYROXSULAM

There total 3 articles about PYROXSULAM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine (13223-43-3) + 2-methoxy-4-(trifluoromethyl)-pyridine-3-sulfonyl chloride (219715-41-0) → pyroxsulam (422556-08-9)

Guidance literature:

5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine; 2-methoxy-4-(trifluoromethyl)-pyridine-3-sulfonyl chloride; With dmap; In dichloromethane; for 0.5h;

With triethylamine; In dichloromethane; at 20 - 35 ℃; for 3h; Temperature;

Reference yield: 83.0%

C15H13F3N6O7S → pyroxsulam (422556-08-9)

Guidance literature:

In toluene; acetonitrile; at 20 - 35 ℃; Inert atmosphere;

DOI:10.1021/op0601518

Reference yield:

N-[N-(4,6-dimethoxypyrimidin-2-yl)-S-methylthiocarbamoyl]-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide → pyroxsulam (422556-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile; toluene / 1.67 h / -5 °C / Inert atmosphere

3: acetonitrile; toluene / 20 - 35 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium carbonate; triethylamine; In dichloromethane; toluene; acetonitrile;

DOI:10.1021/op0601518

upstream raw materials:

5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine

2-methoxy-4-(trifluoromethyl)-pyridine-3-sulfonyl chloride

Refernces

• 1、 -. "A dingding sulphur grass amine preparation method (by machine translation)". Paragraph 0015-0016; 017. . Retrieved 2019/01/06.
• 2、 -. "Process for the preparation of N-([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides". Page/Page column 5. . Retrieved 2008/06/13.