Antineoplaston A10

Base Information

• Chemical Name: Antineoplaston A10
• CAS No.: 77658-84-5
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.266
• Mol file: 77658-84-5.mol

Synonyms:3-(Phenylacetylamino)piperidine-2,6-dione;

Chemical Property of Antineoplaston A10

Chemical Property:

• Vapor Pressure: 4.66E-13mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 571.2 °C at 760 mmHg
• PKA: 10.79±0.40(Predicted)
• Flash Point: 243.7 °C
• PSA: 75.27000
• Density: 1.27 g/cm³
• LogP: 0.87020
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

3-PHENYLACETYLAMINO-2,6-PIPERIDINEDIONE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Antineoplaston A10

There total 2 articles about Antineoplaston A10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

N-benzyloxycarbonyl-L-isoglutamine (6398-06-7) → N-(2,6-dioxopiperidin-3-yl)-2-phenylacetamide (77658-84-5)

Guidance literature:

With dmap; 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 20h; Reflux;

Reference yield: 50.0%

rac-α-aminoglutarimide hydrochloride (24666-56-6,2686-86-4) + phenylacetyl chloride (103-80-0) → N-(2,6-dioxopiperidin-3-yl)-2-phenylacetamide (77658-84-5)

Guidance literature:

rac-α-aminoglutarimide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

phenylacetyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h;

upstream raw materials:

N-benzyloxycarbonyl-L-isoglutamine

rac-α-aminoglutarimide hydrochloride

phenylacetyl chloride

Refernces

• 1、 -. "ACID ADDITION SALTS OF LENALIDOMIDE". Page/Page column 30. . Retrieved 2011/05/11.