3,4,5-Trimethoxybenzonitrile oxide

Base Information

• Chemical Name: 3,4,5-Trimethoxybenzonitrile oxide
• CAS No.: 120802-98-4
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Mol file: 120802-98-4.mol

Synonyms:3,4,5-Trimethoxybenzonitrile oxide

Chemical Property of 3,4,5-Trimethoxybenzonitrile oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5-Trimethoxybenzonitrile oxide

There total 2 articles about 3,4,5-Trimethoxybenzonitrile oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-3,4,5-trimethoxybenzaldehyde oxime (39201-89-3,65567-36-4,65567-39-7) → 3,4,5-Trimethoxybenzonitrile oxide (120802-98-4)

Guidance literature:

With chloroamine-T; In methanol; at 25 ℃; for 0.05h;

DOI:10.1055/s-1989-27152

Reference yield:

3,4,5-trimethoxybenzaldehyde oxime (39201-89-3) → 3,4,5-Trimethoxybenzonitrile oxide (120802-98-4)

Guidance literature:

With chloroamine-T; In ethanol; at 20 ℃; for 0.0333333h;

Reference yield: 90.0%

PVS (5535-48-8) + 3,4,5-Trimethoxybenzonitrile oxide (120802-98-4) → 5-Benzenesulfonyl-3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazole

Guidance literature:

In dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1080/00397919708006048

upstream raw materials:

(E)-3,4,5-trimethoxybenzaldehyde oxime

3,4,5-trimethoxybenzaldehyde oxime

Downstream raw materials:

3-(3',4',5'-trimethoxyphenyl)-5-(3'',4''-dimethoxybenzyl)-4,5-dihydroisoxazole

Refernces

• 1、 Jayashankar,Lokanath Rai,Baskaran,Sathish. "Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents". experimental part. p. 3898 - 3902. Retrieved 2009/12/09.
• 2、 Rai, K.M. Lokanatha,Hassner. "Intermolecular 1,3-dipolar cycloadditions of preformed nitrile oxides with phenyl vinyl sulphone". . p. 467 - 472. Retrieved 2007/10/03.