2,6-Pyridinedicarboxamide

Base Information

• Chemical Name: 2,6-Pyridinedicarboxamide
• CAS No.: 4663-97-2
• Molecular Formula: C7H7N3O2
• Molecular Weight: 165.151
• Hs Code.: 2933399090
• European Community (EC) Number: 627-595-5
• DSSTox Substance ID: DTXSID10357532
• Nikkaji Number: J921.331G
• Wikidata: Q82137486
• ChEMBL ID: CHEMBL443107
• Mol file: 4663-97-2.mol

Synonyms:pyridine-2,6-dicarboxamide

Chemical Property of 2,6-Pyridinedicarboxamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 317oC (dec.)(lit.)
• Refractive Index: 1.621
• Boiling Point: 479.549 °C at 760 mmHg
• PKA: 14.33±0.50(Predicted)
• Flash Point: 243.823 °C
• PSA: 99.07000
• Density: 1.376 g/cm³
• LogP: 0.68000
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.053826475
• Heavy Atom Count: 12
• Complexity: 185

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Pyridinedicarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)C(=O)N)C(=O)N
• Uses: 2,6-Pyridinedicarboxamide may be used in the preparation of new molecular turnstiles based on Sn-porphyrin derivatives.

Technology Process of 2,6-Pyridinedicarboxamide

There total 2 articles about 2,6-Pyridinedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

pyridine-2,6-dinitrile (2893-33-6) → 6-Cyan-pyridin-2-carbonsaeure-amid (52368-18-0) + pyridine-2,6-dicarboxylic acid diamide (4663-97-2)

Guidance literature:

With ((1,2-bis(diisopropylphosphino)ethane)NiH)2; water; at 100 ℃; for 120h; Inert atmosphere;

DOI:10.1016/j.ica.2009.07.002

Reference yield:

pyridine-2,6-dinitrile (2893-33-6) → Pyridine-2,6-dicarboxylic acid (499-83-2) + pyridine-2,6-dicarboxylic acid diamide (4663-97-2)

Guidance literature:

With sulfuric acid; for 5h; Heating; rate of hydrolysis in various acidic medium;

DOI:10.1007/BF00771778

Reference yield: 90.0%

pyridine-2,6-dicarboxylic acid diamide (4663-97-2) → pyridine-2,6-dinitrile (2893-33-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1007/BF00505773

upstream raw materials:

pyridine-2,6-dinitrile

Downstream raw materials:

2.6-diaminopyridine

pyridine-2,6-dinitrile

pyridine-2,6-dicarbothioamide

2,6-bis(aminomethyl)pyridine

Refernces

• 1、 Evstratova, M. I.,Prokopov, A. A.,Ivanova, I. L.,Markova, I. G.,Tubina, I. S.,et al.. "STUDY OF HYDROLYSIS PROCESSES OF 2,6-DICYANOPYRIDINE". . p. 126 - 129. Retrieved 2007/10/02.