1-BENZYL-3-METHOXY-1H-INDAZOLE

Base Information

• Chemical Name: 1-BENZYL-3-METHOXY-1H-INDAZOLE
• CAS No.: 4454-33-5
• Molecular Formula: C15H14 N2 O
• Molecular Weight: 238.28446
• Hs Code.: 2933990090
• Mol file: 4454-33-5.mol

Synonyms:1H-Indazole,1-benzyl-3-methoxy- (7CI,8CI)

Chemical Property of 1-BENZYL-3-METHOXY-1H-INDAZOLE

Chemical Property:

• PSA: 27.05000
• LogP: 3.09320

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Benzyl-3-methoxy-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Benzyl-3-methoxy-1H-indazole is a redox-active 5-kipoxygenase inhibitor.

Technology Process of 1-BENZYL-3-METHOXY-1H-INDAZOLE

There total 3 articles about 1-BENZYL-3-METHOXY-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-benzyl-1,2-dihydro-3H-indazol-3-one (2215-63-6) → 1-benzyl-2-methyl-1,2-dihydro-indazol-3-one (4454-32-4) + 1-benzyl-3-methoxy-1H-indazole (4454-33-5)

Guidance literature:

In diethyl ether; dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/jm00107a023

Reference yield: 52.0%

bendazac (20187-55-7) → 1-benzyl-3-methoxy-1H-indazole (4454-33-5)

Guidance literature:

With 2,4,6-trimethyl-pyridine; ammonium peroxydisulfate; cyclohexa-1,4-diene; In dimethylsulfoxide-d6; at 60 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c04079

Reference yield:

→ 1-benzyl-3-methoxy-1H-indazole (4454-33-5)

Guidance literature:

Neben 1-Benzyl-2-methyl-indazolin-3-on aus 1-Benzyl-3-hydroxy-1H-indazol in einem Ae.-Me.-Gem. m. aether. Diazomethan bei 0grad;

upstream raw materials:

diazomethane

1-benzyl-1,2-dihydro-3H-indazol-3-one

bendazac

Refernces

• 1、 Bruneau,Delvare,Edwards,McMillan. "Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity". . p. 1028 - 1036. Retrieved 2007/10/02.