2,5-Furandipropanol

Base Information

• Chemical Name: 2,5-Furandipropanol
• CAS No.: 4412-78-6
• Molecular Formula: C₁₀H₁₆O₃
• Molecular Weight: 184.235
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID80442383
• Nikkaji Number: J2.142.978C
• Wikidata: Q82259629
• Mol file: 4412-78-6.mol

Synonyms:4412-78-6;3,3'-(Furan-2,5-diyl)bis(propan-1-ol);2,5-Furandipropanol;Furan-2,5-bis(1-propanol);3-[5-(3-HYDROXYPROPYL)FURAN-2-YL]PROPAN-1-OL;SCHEMBL17537578;DTXSID80442383;AKOS006290835;2-(3'-hydroxypropyl)-5(3'-hydroxypropyl)furan

Chemical Property of 2,5-Furandipropanol

Chemical Property:

• PSA: 53.60000
• LogP: 1.12940
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 184.109944368
• Heavy Atom Count: 13
• Complexity: 113

Purity/Quality:

99%min ^*data from raw suppliers

3-(5-(3-HYDROXY-PROPYL)-FURAN-2-YL)-PROPAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(OC(=C1)CCCO)CCCO

Technology Process of 2,5-Furandipropanol

There total 11 articles about 2,5-Furandipropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

dimethyl 3,3'-(furan-2,5-diyl)dipropionate (1216-19-9) → 3-[5-(3-hydroxy-propyl)-furan-2-yl]-propan-1-ol (4412-78-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/ol060558x

Reference yield: 78.0%

3-[5-(3-oxo-propyl)-furan-2-yl]-propionaldehyde (78466-06-5) → 3-[5-(3-hydroxy-propyl)-furan-2-yl]-propan-1-ol (4412-78-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 12h; Heating;

Reference yield: 71.0%

3-[5-(2-methoxycarbonyl-vinyl)-furan-2-yl]-acrylic acid methyl ester (72643-70-0,97271-31-3) → 3-[5-(3-hydroxy-propyl)-furan-2-yl]-propan-1-ol (4412-78-6)

Guidance literature:

3-[5-(2-methoxycarbonyl-vinyl)-furan-2-yl]-acrylic acid methyl ester; With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ol0479702

upstream raw materials:

3-[5-(3-oxo-propyl)-furan-2-yl]-propionaldehyde

diethyl ether

furan

acrolein

Refernces

• 1、 Webb,Borcherdt. "-". . p. 752. Retrieved 1951.
• 2、 Georgiou, Thomas,Tofi, Maria,Montagnon, Tamsyn,Vassilikogiannakis, Georgios. "A versatile and general one-pot method for synthesizing bis-spiroketal motifs". . p. 1945 - 1948. Retrieved 2007/10/03.