6-bromo-2,4-diphenylquinazoline

Base Information

• Chemical Name: 6-bromo-2,4-diphenylquinazoline
• CAS No.: 1229609-99-7
• Molecular Formula: C₂₀H₁₃BrN₂
• Molecular Weight: 361.241
• Mol file: 1229609-99-7.mol

Synonyms:6-bromo-2,4-diphenylquinazoline

Chemical Property of 6-bromo-2,4-diphenylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-2,4-diphenylquinazoline

There total 25 articles about 6-bromo-2,4-diphenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-benzyl-N′-(4-bromophenyl)benzimidamide (1609460-33-4) → 6-bromo-2,4-diphenylquinazoline (1229609-99-7)

Guidance literature:

With iodine; potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 100 ℃; for 4.5h;

DOI:10.1021/acs.joc.6b02100

Reference yield: 93.0%

2-amino-5-bromobenzophenone (39859-36-4) + benzylamine (100-46-9) → 6-bromo-2,4-diphenylquinazoline (1229609-99-7)

Guidance literature:

With tert.-butylhydroperoxide; water; at 90 ℃; for 12h;

DOI:10.1039/c002454f

Reference yield: 88.0%

benzaldehyde (100-52-7) + 2-amino-5-bromobenzophenone (39859-36-4) → 6-bromo-2,4-diphenylquinazoline (1229609-99-7)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In neat (no solvent); at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1039/d0ob01507e

upstream raw materials:

2-amino-5-bromobenzophenone

benzylamine

5-bromo-2-nitrobenzaldehyde

2-amino-5-bromobenzaldehyde

Refernces

• 1、 Cheung, Wing,Patch, Raymond J.,Player, Mark R.. "Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines". . p. 2368 - 2371. Retrieved 2018/05/25.
• 2、 Zhu, Jianghe,Shao, Yinlin,Hu, Kun,Qi, Linjun,Cheng, Tianxing,Chen, Jiuxi. "Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines". . p. 8596 - 8603. Retrieved 2018/11/27.