1-ETHYNYL-4-(METHYLSULPHONYL)-BENZENE

Base Information

• Chemical Name: 1-ETHYNYL-4-(METHYLSULPHONYL)-BENZENE
• CAS No.: 340771-31-5
• Molecular Formula: C9H8 O2 S
• Molecular Weight: 180.227
• Hs Code.: 2904100000
• Mol file: 340771-31-5.mol

Synonyms:4-(Methanesulfonyl)ethynylbenzene

Chemical Property of 1-ETHYNYL-4-(METHYLSULPHONYL)-BENZENE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• Boiling Point: 327.749°C at 760 mmHg
• Flash Point: 187.645°C
• PSA: 42.52000
• Density: 1.254g/cm³
• LogP: 2.15220
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Ethynyl-4-(methylsulfonyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ETHYNYL-4-(METHYLSULPHONYL)-BENZENE

There total 7 articles about 1-ETHYNYL-4-(METHYLSULPHONYL)-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethyl((4-(methylsulfonyl)phenyl)ethynyl)silane (113854-19-6) → 1‐ethynyl‐4‐(methylsulfonyl)benzene (340771-31-5)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h;

DOI:10.1021/acs.joc.5b02066

Reference yield: 74.0%

4-ethynylthioanisole (56041-85-1) → 1‐ethynyl‐4‐(methylsulfonyl)benzene (340771-31-5)

Guidance literature:

With Oxone; In 1,4-dioxane; at 25 ℃;

DOI:10.1021/jm049939b

Reference yield: 68.0%

1-(4-(methylsulphonyl)phenyl)vinyl trifluoromethanesulphonate → 1‐ethynyl‐4‐(methylsulfonyl)benzene (340771-31-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02403

upstream raw materials:

trimethyl((4-(methylsulfonyl)phenyl)ethynyl)silane

4-ethynylthioanisole

4-bromoohenyl methyl sulfone

4-(methanesulfonyl)acetophenone

Downstream raw materials:

{4-[3-cyclopentylmethoxy-5-(4-methanesulfonyl-phenylethynyl)-phenyl-sulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester

{4-[3-cyclohexylmethoxy-5-(4-methanesulfonyl-phenylethynyl)-phenyl-sulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester

4-[4-(methylsulfonyl)phenyl]-1-[(3-phenylprop-2-yn-1-yl)oxy]but-3-yn-2-one

Refernces

• 1、 Li, Yiming,Rizvi, S. Aal-e-Ali,Hu, Deqing,Sun, Danwen,Gao, Anhui,Zhou, Yubo,Li, Jia,Jiang, Xuefeng. "Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis". supporting information. p. 13499 - 13506. Retrieved 2019/08/21.
• 2、 Purifica??o, Sara I.,Pires, Marina J.D.,Rippel, Rafael,Santos, A. Sofia,Marques, M. Manuel B.. "One-pot synthesis of 1, 2-disubstituted 4-, 5-, 6-, and 7-azaindoles from amino-o-halopyridines via n-arylation/sonogashira/cyclization reaction". . p. 5118 - 5121. Retrieved 2017/11/07.