17B-ACETOXY-6B-HYDROXY-TESTOSTERONE

Base Information

• Chemical Name: 17B-ACETOXY-6B-HYDROXY-TESTOSTERONE
• CAS No.: 4223-43-2
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.467
• Mol file: 4223-43-2.mol

Synonyms:17B-ACETOXY-6B-HYDROXY-TESTOSTERONE;6b-Hydroxy-testosteron-17-acetat;17-Acetoxy 6-Hydroxy Testosterone;6,17-Dihydroxy-9,10a-androst-4-en-3-one 17-Acetate;6-Hydroxy-testosteron-17-acetate

Chemical Property of 17B-ACETOXY-6B-HYDROXY-TESTOSTERONE

Chemical Property:

• Melting Point: 167-170 °C
• Boiling Point: 484.3±45.0 °C(Predicted)
• PKA: 13.95±0.70(Predicted)
• PSA: 63.60000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 3.42080

Purity/Quality:

98%min ^*data from raw suppliers

17-BETA-ACETOXY 6-BETA-HYDROXY TESTOSTERONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Contolled substance. Testosterone derivative Contolled substance. Testosterone (T155000) derivative.

Technology Process of 17B-ACETOXY-6B-HYDROXY-TESTOSTERONE

There total 17 articles about 17B-ACETOXY-6B-HYDROXY-TESTOSTERONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(17β)-androsta-3,5-diene-3,17-diol diacetate (123880-21-7) → 17-(acetyloxy)-6-hydroxyandrost-4-en-3-one (4223-43-2,4223-44-3,13096-48-5,13573-36-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid;

DOI:10.1021/jo00215a011

Reference yield:

3-Methoxy-17β-acetoxy-androsta-3,5-dien (6014-58-0) → androst-4-ene-6β,17β-diol-3-one, 17 acetate (4223-43-2,4223-44-3,13573-36-9,13096-48-5)

Guidance literature:

With (tBuO)2CrO₂; In tetrachloromethane;

DOI:10.1248/cpb.11.1167

Reference yield:

testosterone acetate (1045-69-8) → androst-4-ene-6β,17β-diol-3-one, 17 acetate (4223-43-2,4223-44-3,13573-36-9,13096-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / dioxane

2: (tBuO)2CrO₂ / CCl₄

With toluene-4-sulfonic acid; In 1,4-dioxane; tetrachloromethane;

DOI:10.1248/cpb.11.1167

upstream raw materials:

monoperoxyphthalic acid

diethyl ether

testosterone enol diacetate

3-Ethoxy-2β-chlor-androsta-3,5-dien-17β-ol-acetat

Downstream raw materials:

6β,17β-diacetoxyandrost-4-en-3-one

androsta-4,6-dien-17β-ol-3-one acetate

Refernces

• 1、 Wijnberg, Joannes B. P. A.,Jongedijk, Gerard,Groot, Aede de. "A Simple Acid-Catalyzed Isomerization of &γ-Hydroxy Enones into &γ-Diones". . p. 2650 - 2654. Retrieved 2007/10/02.