4,5,7-TRIHYDROXY-3-PHENYLCOUMARIN

Base Information

• Chemical Name: 4,5,7-TRIHYDROXY-3-PHENYLCOUMARIN
• CAS No.: 4222-02-0
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.241
• Hs Code.: 2932209090
• Mol file: 4222-02-0.mol

Synonyms:Coumarin,4,5,7-trihydroxy-3-phenyl- (6CI,7CI,8CI);3-Phenyl-4,5,7-trihydroxycoumarin;4,5,7-Trihydroxy-3-phenylcoumarin;

Chemical Property of 4,5,7-TRIHYDROXY-3-PHENYLCOUMARIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 268-272 °C
• Refractive Index: 1.748
• Boiling Point: 590.955 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 231.219 °C
• PSA: 90.90000
• Density: 1.579 g/cm³
• LogP: 2.57680

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5,7-Trihydroxy-3-phenylcoumarin 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Technology Process of 4,5,7-TRIHYDROXY-3-PHENYLCOUMARIN

There total 3 articles about 4,5,7-TRIHYDROXY-3-PHENYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-4,6-dimethoxyphenyl benzyl ketone (39604-66-5) → 4,5,7-Trihydroxy-3-phenyl-coumarin (4222-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; acetone

2: aqueous hydriodic acid; acetic acid anhydride

With hydrogen iodide; acetic anhydride; potassium carbonate; acetone;

Reference yield:

4-hydroxy-5,7-dimethoxy-3-phenylcoumarin (4222-00-8) → 4,5,7-Trihydroxy-3-phenyl-coumarin (4222-02-0)

Guidance literature:

With hydrogen iodide; acetic anhydride;

Reference yield:

2-phenyl-2',4',6'-trihydroxyacetophenone (727-71-9) + methyl chloroformate (79-22-1) → 4,5,7-Trihydroxy-3-phenyl-coumarin (4222-02-0)

Guidance literature:

With potassium carbonate; acetone; Behandeln des Reaktionsprodukts mit wss. Natronlauge;

upstream raw materials:

4-hydroxy-5,7-dimethoxy-3-phenylcoumarin

2-phenyl-2',4',6'-trihydroxyacetophenone

methyl chloroformate

2-hydroxy-4,6-dimethoxyphenyl benzyl ketone

Downstream raw materials:

4,5,7-triacetoxy-3-phenyl-coumarin