VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)

Base Information

• Chemical Name: VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
• CAS No.: 330808-88-3
• Molecular Formula: C23H32 N6 O4 S . Cl H . 3 H2 O
• Molecular Weight: 579.10976
• Hs Code.: 2933595960
• Mol file: 330808-88-3.mol

Synonyms:Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-,monohydrochloride, trihydrate (9CI); Vardenafil hydrochloride trihydrate

Chemical Property of VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O

Purity/Quality:

99%, ^*data from raw suppliers

Vardenafil hydrochloride trihydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.
• Uses: Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]