Technology Process of methyl (R)-2-((2S,4R)-2,4-dimethylheptanamido)-2-phenylacetate
There total 6 articles about methyl (R)-2-((2S,4R)-2,4-dimethylheptanamido)-2-phenylacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 7.5h;
DOI:10.1016/j.tet.2012.04.075
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 4 h / -78 - 0 °C / Inert atmosphere
1.3: Saturated solution
2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h / 0 °C
2.2: pH < 2
3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 7.5 h / 20 °C
With
1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.075
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h / 0 °C
1.2: pH < 2
2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 7.5 h / 20 °C
With
1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.075