5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE

Base Information

• Chemical Name: 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE
• CAS No.: 4027-55-8
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.157
• Hs Code.: 29331990
• Mol file: 4027-55-8.mol

Synonyms:Pyrazole-3(or5)-carboxamide, N,5(or N,3)-dimethyl- (7CI); Pyrazole-3-carboxamide,N,5-dimethyl- (8CI); 3-Methylcarboxamido-5-methylpyrazole

Chemical Property of 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE

Chemical Property:

• Melting Point: 163-168℃
• PSA: 57.78000
• LogP: 0.46860

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-1H-pyrazole-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE

There total 5 articles about 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Diazoethan (1117-96-0) + N-methyl-(Z)-3-chloro-2-(phenylsulfinyl)propenamide (1093762-14-1) → N,5-dimethyl-1H-pyrazole-3-carboxamide (4027-55-8)

Guidance literature:

In diethyl ether; acetone; at -20 - 20 ℃; regioselective reaction;

DOI:10.1039/c002479a

Reference yield: 40.0%

ethyl 5-methyl-1H-pyrazole-3-carboxylate (4027-57-0) + methylamine (74-89-5) → N,5-dimethyl-1H-pyrazole-3-carboxamide (4027-55-8)

Guidance literature:

In methanol; for 72h;

DOI:10.3390/molecules24142632

Reference yield:

C6H9NO3 → N,5-dimethyl-1H-pyrazole-3-carboxamide (4027-55-8)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmcl.2017.07.004

upstream raw materials:

Diazoethan

N-methyl-(Z)-3-chloro-2-(phenylsulfinyl)propenamide

ethyl 5-methyl-1H-pyrazole-3-carboxylate

methylamine

Refernces

• 1、 Fukuda, Takeshi,Goto, Riki,Kiho, Toshihiro,Ueda, Kenjiro,Muramatsu, Sumie,Hashimoto, Masami,Aki, Anri,Watanabe, Kengo,Tanaka, Naoki. "Discovery of DS79182026: A potent orally active hepcidin production inhibitor". . p. 3716 - 3722. Retrieved 2017/07/27.
• 2、 Kissane, Marie,Lawrence, Simon E.,Maguire, Anita R.. "1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes". supporting information; experimental part. p. 2735 - 2748. Retrieved 2010/08/21.