Technology Process of 4-(4-bromophenyl)-2,2-dimethylbut-3-ynenitrile
There total 3 articles about 4-(4-bromophenyl)-2,2-dimethylbut-3-ynenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
8-quinolinol; silver carbonate; copper(I) bromide;
In
N,N-dimethyl acetamide;
at 130 ℃;
for 16h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ol400197y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.25 h / 0 °C / Schlenk technique; Inert atmosphere
2: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / water; dichloromethane / 0 °C / Schlenk technique; Inert atmosphere
3: copper(I) bromide; 8-quinolinol; silver carbonate / N,N-dimethyl acetamide / 16 h / 130 °C / Schlenk technique; Inert atmosphere
With
8-quinolinol; carbon tetrabromide; N-benzyl-N,N,N-triethylammonium chloride; triphenylphosphine; silver carbonate; potassium hydroxide; copper(I) bromide;
In
dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/ol400197y
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / water; dichloromethane / 0 °C / Schlenk technique; Inert atmosphere
2: copper(I) bromide; 8-quinolinol; silver carbonate / N,N-dimethyl acetamide / 16 h / 130 °C / Schlenk technique; Inert atmosphere
With
8-quinolinol; N-benzyl-N,N,N-triethylammonium chloride; silver carbonate; potassium hydroxide; copper(I) bromide;
In
dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/ol400197y