4-Hydroxypyridine-2,6-dicarboxylic acid

Base Information

• Chemical Name: 4-Hydroxypyridine-2,6-dicarboxylic acid
• CAS No.: 499-51-4
• Molecular Formula: C7H5NO5
• Molecular Weight: 183.12
• Hs Code.: 2933399990
• Mol file: 499-51-4.mol

Synonyms:4-Hydroxydipicolinic acid;4-Hydroxypyridine-2,6-dicarboxylic acid;2,6-Dicarboxy-4-hydroxypyridine;Helidaminicacid;Chelidamic acid;4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid;

Chemical Property of 4-Hydroxypyridine-2,6-dicarboxylic acid

Chemical Property:

• Melting Point: 251-255 °C (decomp)(Solv: water (7732-18-5))
• Boiling Point: 428.3 °C at 760 mmHg
• PKA: 0.61±0.50(Predicted)
• Flash Point: 212.8 °C
• PSA: 107.72000
• Density: 1.726 g/cm³
• LogP: 0.18360
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Aqueous Base (Slightly, Heated, Sonicated)

Purity/Quality:

98%min ^*data from raw suppliers

HelidaminicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Helidaminic Acid is a catalyst used for preparation of substituted methylquinolines in palladium pyridinedicarboxylic acid systems.

Technology Process of 4-Hydroxypyridine-2,6-dicarboxylic acid

There total 12 articles about 4-Hydroxypyridine-2,6-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chelidonic acid (99-32-1) → Chelidamic acid (499-51-4)

Guidance literature:

With ammonium hydroxide; In water; at 100 ℃; for 5h;

DOI:10.1039/b206782j

Reference yield: 95.5%

2,6-dicarboxyl-γ-pyrone → Chelidamic acid (499-51-4)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 48h; Cooling with ice;

Reference yield: 92.3%

Dimethyl oxalate (553-90-2) + acetone (67-64-1) → Chelidamic acid (499-51-4)

Guidance literature:

Dimethyl oxalate; acetone; With sodium ethanolate; In ethanol; at 70 ℃; for 2h;

With hydrogenchloride; In water; at 100 ℃;

With ammonium hydroxide; at 0 ℃; for 48h; Reagent/catalyst; Temperature;

upstream raw materials:

4-amino-2,6-pyridinedicarboxylic acid

4-chloro-2,6-pyridinedicarboxylic acid

chelidonic acid

2,6-dimethylpyridin-4-ol

Downstream raw materials:

dimethyl 4-methoxypyridine-2,6-dicarboxylate

4-chloro-2,6-pyridinedicarboxylic acid

4-hydroxypyridine-2,6-dicarboxylic acid diethylester

dimethyl 4-hydroxypyridine-2,6-dicarboxylate

Refernces

• 1、 Alves, Filipe,Golesorkhi, Bahman,Guénée, Laure,Naseri, Soroush,Nozary, Homayoun,Piguet, Claude,Taarit, Inès. "Ligand-Sensitized Near-Infrared to Visible Linear Light Upconversion in a Discrete Molecular Erbium Complex". supporting information. p. 15326 - 15334. Retrieved 2021/09/30.
• 2、 -. "Preparing method of 4-hydroxypyridine-2,6-dicarboxylic acid". Paragraph 0028-0062. . Retrieved 2019/10/01.