2-methylbenzoyl fluoride

Base Information

• Chemical Name: 2-methylbenzoyl fluoride
• CAS No.: 364-20-5
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.141
• Mol file: 364-20-5.mol

Synonyms:2-methylbenzoyl fluoride

Chemical Property of 2-methylbenzoyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-methylbenzoyl fluoride

There total 4 articles about 2-methylbenzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-methylbenzoic anhydride (607-86-3) → 2-methylbenzoyl fluoride (364-20-5)

Guidance literature:

With benzoyl fluoride; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 80 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.organomet.0c00028

Reference yield: 44.0%

ortho-toluoyl chloride (933-88-0) → 2-methylbenzoyl fluoride (364-20-5)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at 40 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c8cc08504h

Reference yield:

ortho-methylbenzoic acid (118-90-1) → 2-methylbenzoyl fluoride (364-20-5)

Guidance literature:

With pyridine; trifluoro-[1,3,5]triazine; In acetonitrile;

DOI:10.1055/s-1973-22238

upstream raw materials:

ortho-methylbenzoic acid

2-methylphenyl bromide

3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

ortho-toluoyl chloride

Downstream raw materials:

N-benzyl-2-methylbenzamide

3-phenyl-3-(trifluoromethyl)isochroman-1-one

2-Methylbenzonitrile

1-phenylethynyltoluene

Refernces

• 1、 Agrawal, Arush,G?tze, Jan P.,Golz, Paul,Hopkinson, Matthew N.,Mavroskoufis, Andreas,Rajes, Keerthana,Ru?, Vincent. "N-Heterocyclic Carbene Catalyzed Photoenolization/Diels–Alder Reaction of Acid Fluorides". . p. 3190 - 3194. Retrieved 2020/01/24.
• 2、 Ogiwara, Yohei,Hosaka, Shintaro,Sakai, Norio. "Benzoyl Fluorides as Fluorination Reagents: Reconstruction of Acyl Fluorides via Reversible Acyl C-F Bond Cleavage/Formation in Palladium Catalysis". . p. 856 - 861. Retrieved 2020/03/05.