4-bromopyrrolo[1,2-f][1,2,4]triazine

Base Information

• Chemical Name: 4-bromopyrrolo[1,2-f][1,2,4]triazine
• CAS No.: 310436-61-4
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.02
• Hs Code.: 2933990090
• Mol file: 310436-61-4.mol

Synonyms:4-bromopyrrolo[1,2-f][1,2,4]triazine;2-f][1;4]triazine;4-broMopyrrolo[1;4-BroMopyrrolo[2,1-f][1,2,4]triazine

Chemical Property of 4-bromopyrrolo[1,2-f][1,2,4]triazine

Chemical Property:

• Refractive Index: 1.637
• PKA: -2.81±0.30(Predicted)
• PSA: 30.19000
• Density: 1.891 g/cm³
• LogP: 1.49180
• Storage Temp.: -20°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromopyrrolo[2,1-f][1,2,4]triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromopyrrolo[2,1-f][1,2,4]triazine is a reagent used in the preparation of heterobiaryls via heteroarylation of azine N-oxides.

Technology Process of 4-bromopyrrolo[1,2-f][1,2,4]triazine

There total 7 articles about 4-bromopyrrolo[1,2-f][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one (159326-71-3) → 4-bromo-pyrrolo[2,1-f][1,2,4]triazine (310436-61-4)

Guidance literature:

With phosphorus(V) oxybromide; at 60 ℃;

DOI:10.1021/jm049892u

Reference yield:

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one (159326-71-3) → 4-bromo-pyrrolo[2,1-f][1,2,4]triazine (310436-61-4)

Guidance literature:

With phosphorus(V) oxybromide;

Reference yield:

N-amino-1H-pyrrole-2-carbonitrile (159326-66-6) → 4-bromo-pyrrolo[2,1-f][1,2,4]triazine (310436-61-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. KOH

2.1: NaOAc

2.2: MeONa / methanol

3.1: POBr₃ / 60 °C

With potassium hydroxide; sodium acetate; phosphorus(V) oxybromide;

DOI:10.1021/jm049892u

upstream raw materials:

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one

2-pyrrole aldehyde

N-amino-1H-pyrrole-2-carbonitrile

1-aminopyrrole-2-carboxamide

Refernces

• 1、 -. "Pyrrolotriazine inhibitors of kinases". Page/Page column 20-21. . Retrieved 2008/06/13.
• 2、 -. "Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors". . . Retrieved 2008/06/13.