1,1,1-TRIFLUORO-2-BUTANOL

Base Information

• Chemical Name: 1,1,1-TRIFLUORO-2-BUTANOL
• CAS No.: 431-36-7
• Molecular Formula: C4H7 F3 O
• Molecular Weight: 128.09
• Hs Code.: 2905599890
• Mol file: 431-36-7.mol

Synonyms:1,1,1-Trifluoro-2-butanol;1,1,1-Trifluoro-2-butyl alcohol

Chemical Property of 1,1,1-TRIFLUORO-2-BUTANOL

Chemical Property:

• Refractive Index: 1.3403
• Boiling Point: 95.7°Cat760mmHg
• PKA: 12.53±0.20(Predicted)
• Flash Point: 50.9°C
• PSA: 20.23000
• Density: 1.176g/cm³
• LogP: 1.31960

Purity/Quality:

98%Min ^*data from raw suppliers

1,1,1-Trifluorobutan-2-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1,1-TRIFLUORO-2-BUTANOL

There total 9 articles about 1,1,1-TRIFLUORO-2-BUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,1,1-trifluoro-2-butanone (381-88-4) → 1,1,1-trifluoro-2-butanol (431-36-7)

Guidance literature:

With formic acid; tetrabutylammomium bromide; water; potassium formate; RuCl[(R,R)-Tsdpen](mesitylene); at 30 ℃; for 21h; Inert atmosphere; Autoclave;

Reference yield:

1,1,1-Trifluor-2-butanamin-hydrochlorid (758-33-8) → trans-1,1,1-Trifluor-2-buten (31450-05-2) + 1,1,1-trifluoro-2-butanol (431-36-7) + 4,4,4-trifluoro-2-butanol (101054-93-7) + 1,1,1-Trifluor-2-diazobutan (101054-92-6)

Guidance literature:

With sodium nitrite; In perchloric acid; Product distribution; Mechanism; pH: 3.5 - 2.8;

Reference yield:

trifluoroacetic acid-methyl ester (431-47-0) + isopropylmagnesium bromide (920-39-8) → 1,1,1-trifluoro-2-butanol (431-36-7) + 3-methyl-1,1,1-trifluorobutan-2-ol (382-02-5)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01120a525

upstream raw materials:

1,1,1-trifluoro-2,3-epoxypropane

methylmagnesium bromide

n-butyl trifluoroacetate

ethylmagnesium bromide

Downstream raw materials:

4-Brom-benzolsulfonsaeure-<1-trifluormethyl-propylester>

Refernces

• 1、 -. "Process for producing optically active aliphatic fluoroalcohol". Page/Page column 14. . Retrieved 2012/01/11.
• 2、 Kuchin, A. V.,Homutov, O. G.,Filyakova, V. I.,Paschkevich, K. I.. "ALANES IN SYNTHESIS OF FLUORINATED FUNCTIONAL COMPOUNDS". . p. 220. Retrieved 2007/10/02.