2-Fluoro-2-iodoacetamide

Base Information

• Chemical Name: 2-Fluoro-2-iodoacetamide
• CAS No.: 431-13-0
• Molecular Formula: C₂H₃FINO
• Molecular Weight: 202.955
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID60382051
• Mol file: 431-13-0.mol

Synonyms:2-fluoro-2-iodoacetamide;Iodofluoroacetamide;431-13-0;Fluoroiodoacetamide;fluoroiodoethanamide;DTXSID60382051;MFCD04038312;AKOS015852819;CS-0452474;EN300-7418208

Chemical Property of 2-Fluoro-2-iodoacetamide

Chemical Property:

• Vapor Pressure: 0.00426mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 278.5°C at 760 mmHg
• PKA: 13.40±0.50(Predicted)
• Flash Point: 122.2°C
• PSA: 43.09000
• Density: 2.332g/cm³
• LogP: 0.90260
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 202.92434
• Heavy Atom Count: 6
• Complexity: 66.6

Purity/Quality:

98%Min ^*data from raw suppliers

Iodofluoroacetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)N)(F)I

Technology Process of 2-Fluoro-2-iodoacetamide

There total 1 articles about 2-Fluoro-2-iodoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-fluoro-2-iodoacetate (401-58-1) → fluoro-iodo-acetic acid amide (431-13-0)

Guidance literature:

With ammonia;

Reference yield: 30.0%

fluoro-iodo-acetic acid amide (431-13-0) + benzaldehyde (100-52-7) → 2-fluoro-3-phenylpropenamide (100908-66-5)

Guidance literature:

With triethylarsine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 110 ℃; for 24h;

upstream raw materials:

ethyl 2-fluoro-2-iodoacetate

Downstream raw materials:

2-fluoro-3-phenylpropenamide