6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL

Base Information

• Chemical Name: 6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL
• CAS No.: 429-01-6
• Molecular Formula: C9H9 F9 O3
• Molecular Weight: 336.154
• Hs Code.: 2932999099
• Mol file: 429-01-6.mol

Synonyms:Pyran-2,4-diol,tetrahydro-6-methyl-2,4,6-tris(trifluoromethyl)- (6CI,7CI,8CI)

Chemical Property of 6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL

Chemical Property:

• Vapor Pressure: 0.00427mmHg at 25°C
• Melting Point: 107.5-108.5 °C
• Refractive Index: 1.37
• Boiling Point: 247.1°C at 760 mmHg
• PKA: 9.32±0.60(Predicted)
• Flash Point: 121°C
• PSA: 49.69000
• Density: 1.632g/cm³
• LogP: 2.66210

Purity/Quality:

97% ^*data from raw suppliers

6-Methyl-2,4,6-tris(trifluoromethyl)tetrahydropyran-2,4-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL

There total 5 articles about 6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,1,1-trifluoro-2-propanone (421-50-1) → 2,4-dihydroxy 2,4,6-tri-(perfluoro methyl) 6-methyl tetrahydro pyrane (429-01-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

1,1,1-trifluoro-2-propanone (421-50-1) + trifluorovinyllithium (683-78-3) → 2,4-dihydroxy 2,4,6-tri-(perfluoro methyl) 6-methyl tetrahydro pyrane (429-01-6)

Guidance literature:

In diethyl ether; byproducts: CF2CF(CH3)2COH; CF2CFLi: reaction of CH3Li and CF2CFBr; addition of CH3Li (at first) and CF3COCH3 to the bromide at -50 - -40°C and warming to 20°C within 3 hours;; 28 % CF2CF(CH3)2COH;;

DOI:10.1021/jo01038a063

Reference yield:

1,1,1-trifluoro-2-propanone (421-50-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 2,4-dihydroxy 2,4,6-tri-(perfluoro methyl) 6-methyl tetrahydro pyrane (429-01-6)

Guidance literature:

Multistep reaction; (i) nBuLi, (ii) /BRN= 1748614/;

DOI:10.1021/jo01265a055

upstream raw materials:

1,1,1-trifluoro-2-propanone

2-bromo-3,3,3-trifluoropropene

trifluorovinyllithium

Downstream raw materials:

2-methyl-2,4,6-tris-(trifluoromethyl)pyran

Refernces

• 1、 -. "Fluorinated acrylic compounds, methods for preparation of the compounds and photoresist compositions containing same". Page 9. . Retrieved 2008/06/13.