Technology Process of C22H28O8
There total 6 articles about C22H28O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-methoxy-2,3-bis(methoxymethoxy)-4-((3,4,5-trimethoxyphenyl)-ethynyl)benzene;
With
bis(cyclohexanyl)borane;
at 0 - 20 ℃;
With
acetic acid;
at 0 ℃;
for 4h;
DOI:10.1016/S0040-4039(02)00389-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 5 g / E. coli JM109 (pDTG602); fermentation broth / 2 h / fermentation
2.1: 90 percent / EtN(i-Pr)2 / CH2Cl2
3.1: n-BuLi; B(Oi-Pr)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / -78 °C
3.2: Pd(PPh3)4 / 90 °C / Suzuki-Miyaura coupling
4.1: (C6H11)2BH / 0 - 20 °C
4.2: 84 percent / HOAC / 4 h / 0 °C
With
n-butyllithium; fermentation broth; Triisopropyl borate; E. coli JM109 (pDTG602); bis(cyclohexanyl)borane; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/S0040-4039(02)00389-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi; B(Oi-Pr)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / -78 °C
1.2: Pd(PPh3)4 / 90 °C / Suzuki-Miyaura coupling
2.1: (C6H11)2BH / 0 - 20 °C
2.2: 84 percent / HOAC / 4 h / 0 °C
With
n-butyllithium; Triisopropyl borate; bis(cyclohexanyl)borane;
In
tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(02)00389-1