Technology Process of 4-[(3-fluorophenyl)amino]-6-methoxy-7-(prop-2-ynyloxy)quinazoline
There total 8 articles about 4-[(3-fluorophenyl)amino]-6-methoxy-7-(prop-2-ynyloxy)quinazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide; toluene;
at 50 - 60 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: nitric acid / acetic acid
2: sodium tetrahydroborate; nickel(II) chloride hexahydrate
3: formamide
4: thionyl chloride / N,N-dimethyl-formamide
5: isopropyl alcohol
6: trifluoroacetic acid / dichloromethane
7: potassium carbonate / N,N-dimethyl-formamide; toluene / 16 h / 50 - 60 °C
With
sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; nitric acid; potassium carbonate; trifluoroacetic acid;
In
dichloromethane; formamide; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.tetlet.2010.11.107
- Guidance literature:
-
Multi-step reaction with 5 steps
1: formamide
2: thionyl chloride / N,N-dimethyl-formamide
3: isopropyl alcohol
4: trifluoroacetic acid / dichloromethane
5: potassium carbonate / N,N-dimethyl-formamide; toluene / 16 h / 50 - 60 °C
With
thionyl chloride; potassium carbonate; trifluoroacetic acid;
In
dichloromethane; formamide; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.tetlet.2010.11.107