2,3-dihydrobenzofuran-6-carboxylic acid

Base Information

• Chemical Name: 2,3-dihydrobenzofuran-6-carboxylic acid
• CAS No.: 301836-57-7
• Molecular Formula: C9H8O3
• Molecular Weight: 164.15802
• Hs Code.: 2932999099
• Mol file: 301836-57-7.mol

Synonyms:2,3-Dihydrobenzofuran-6-carboxylicacid;2,3-dihydro-1-benzofuran-6-carboxylic acid;6-benzofurancarboxylic acid, 2,3-dihydro-;

Chemical Property of 2,3-dihydrobenzofuran-6-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 322.8 °C at 760 mmHg
• PKA: 4.25±0.20(Predicted)
• Flash Point: 136 °C
• PSA: 46.53000
• Density: 1.344 g/cm³
• LogP: 1.31970
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydrobenzofuran-6-carboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydrobenzofuran-6-carboxylic acid

There total 3 articles about 2,3-dihydrobenzofuran-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

methyl 2,3-dihydrobenzofuran-6-carboxylate (1083168-68-6) + trifluoro-methanesulfonic acid 2,3-dihydro-benzofuran-6-yl ester (189035-25-4) + [PdBr2(PPh3)2] → 2,3-dihydrobenzo[b]furan-6-carboxylic acid (301836-57-7)

Guidance literature:

With sodium hydroxide; tributyl-amine; carbon monoxide; In ethyl acetate;

Reference yield:

C12H14O3Si → 2,3-dihydrobenzo[b]furan-6-carboxylic acid (301836-57-7)

Guidance literature:

With copper(l) iodide; triethylamine; In methanol; at 65 ℃; for 3h; Temperature;

Reference yield:

3-Carboxyphenol (99-06-9) → 2,3-dihydrobenzo[b]furan-6-carboxylic acid (301836-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; sodium hypochlorite; sodium iodide / methanol; water / 2 h / -10 - -5 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

3: copper(l) iodide; triethylamine / methanol / 3 h / 65 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hypochlorite; copper(l) iodide; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; water;

upstream raw materials:

methyl 2,3-dihydrobenzofuran-6-carboxylate

trifluoro-methanesulfonic acid 2,3-dihydro-benzofuran-6-yl ester

3-Carboxyphenol

Downstream raw materials:

2,3-dihydrobenzofuran-6-carbonyl chloride

Refernces

• 1、 -. "Triarylimidazoles". . . Retrieved 2008/06/13.