2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

Base Information

• Chemical Name: 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid
• CAS No.: 300657-03-8
• Molecular Formula: C31H26 N2 O3
• Molecular Weight: 474.55
• Hs Code.: 2933199090
• UNII: M5X9XSU6J5
• ChEMBL ID: CHEMBL247920
• Nikkaji Number: J2.467.525D
• Pharos Ligand ID: M9G6WXGT96UW
• Wikidata: Q27075342
• Mol file: 300657-03-8.mol

Synonyms:2-(2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy)acetic acid;BMS 309403;BMS-309403;BMS309403

Chemical Property of 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

Chemical Property:

• Boiling Point: 657.5±55.0 °C(Predicted)
• PKA: 3.15±0.10(Predicted)
• PSA: 64.35000
• Density: 1.17
• LogP: 6.89910
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in DMSO (up to at lease 25 mg/ml).
• XLogP3: 7.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 474.19434270
• Heavy Atom Count: 36
• Complexity: 689

Purity/Quality:

99% ^*data from raw suppliers

BMS 309403 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5
• Description: BMS 309403 is a potent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (Ki values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity.
• Uses: FABP4 Inhibitor is a cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of A-FABP (adipocyte Fatty-Acid-Binding Protein) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP''s (Ki = 250 nM and 350 nM, respectively).