(2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID

Base Information

• Chemical Name: (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID
• CAS No.: 31137-95-8
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 31137-95-8.mol

Synonyms:(4R)-4-Methyl-D-proline;

Chemical Property of (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.00694mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 250.2 °C at 760 mmHg
• Flash Point: 105.1 °C
• PSA: 49.33000
• Density: 1.104 g/cm³
• LogP: 0.39780

Purity/Quality:

99.3% ^*data from raw suppliers

(4R)-4-Methyl-D-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID

There total 5 articles about (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2R,4R)-4-methyl-N-(9-(9-phenylfluorenyl))proline tert-butyl ester (326811-95-4) → (2R,4R)-4-methylproline (31137-95-8)

Guidance literature:

DOI:10.1016/S0040-4020(00)00764-X

Reference yield:

C7H13NO2 → (2R,4R)-4-methylproline (31137-95-8)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane;

DOI:10.1055/s-0029-1219372

Reference yield:

α-tert-butyl (2R,4R)-5-hydroxy-4-methyl-2-N-(9-(9-phenylfluorenyl)amino)pentanoate (326859-52-3) → (2R,4R)-4-methylproline (31137-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent

2: 88 percent

1: Cyclization / 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00764-X

upstream raw materials:

(2R,4R)-4-methyl-N-(9-(9-phenylfluorenyl))proline tert-butyl ester

α-tert-butyl (2R,4R)-5-hydroxy-4-methyl-2-N-(9-(9-phenylfluorenyl)amino)pentanoate

Refernces

• 1、 Golakoti, Trimurtulu,Yoshida, Wesley Y.,Chaganty, Sreedhara,Moore, Richard E.. "Isolation and structures of nostopeptolides A1, A2 and A3 from the cyanobacterium Nostoc sp. GSV224". . p. 9093 - 9102. Retrieved 2007/10/03.