1-Methoxy-3-Methylcarbazole

Base Information

• Chemical Name: 1-Methoxy-3-Methylcarbazole
• CAS No.: 4532-33-6
• Molecular Formula: C14H13 N O
• Molecular Weight: 211.263
• Hs Code.: 2933990090
• Mol file: 4532-33-6.mol

Synonyms:Carbazole,1-methoxy-3-methyl- (7CI,8CI); 1-Methoxy-3-methylcarbazole; Murrayafoline A;NSC 654284

Chemical Property of 1-Methoxy-3-Methylcarbazole

Chemical Property:

• PSA: 25.02000
• LogP: 3.63810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥98% ^*data from raw suppliers

1-methoxy-3-methyl-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methoxy-3-Methylcarbazole

There total 63 articles about 1-Methoxy-3-Methylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C21H19NO3S → 1-methoxy-3-methylcarbazole (4532-33-6)

Guidance literature:

With magnesium; In tetrahydrofuran; methanol; at 70 ℃; for 4h;

DOI:10.1002/adsc.201801265

Reference yield: 92.0%

sodium methylate (124-41-4) + 1-bromo-3-methyl-9H-carbazole (387819-80-9) → 1-methoxy-3-methylcarbazole (4532-33-6)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1021/jo016124r

Reference yield: 88.0%

(2-methoxy-4-methylphenyl)phenylamine (808114-08-1) → 1-methoxy-3-methylcarbazole (4532-33-6)

Guidance literature:

With copper diacetate; palladium diacetate; In N,N-dimethyl-formamide; at 130 ℃; for 1h; Sealed tube; Microwave irradiation;

DOI:10.1002/ejoc.200900537

upstream raw materials:

methanol

1-indol-2-yl-3-methylbutane-1,4-dione

boron trifluoride methanol complex

1-methoxy-9-[(1-methoxycarbazol-3-yl)-methyl]-3-methylcarbazole

Downstream raw materials:

1-hydroxy-3-methyl-9H-carbazole

murrayaquinone A

C₃₆H₃₀N₂O₆S

1-methoxy-9-[(1-methoxycarbazol-3-yl)-methyl]-3-methylcarbazole

Refernces

• 1、 Mal, Dipakranjan,Roy, Joyeeta. "Total synthesis of clausamine e and furanoclausamine B". . p. 1247 - 1253. Retrieved 2015.
• 2、 Bhatthula, Bharath kumar goud,Kanchani, Janardhan reddy,Arava, Veera reddy,Subha. "Total synthesis of carbazole alkaloids". . p. 874 - 887. Retrieved 2019/01/11.
• 3、 Chakraborti, Gargi,Paladhi, Sushovan,Mandal, Tirtha,Dash, Jyotirmayee. ""on Water" Promoted Ullmann-Type C-N Bond-Forming Reactions: Application to Carbazole Alkaloids by Selective N-Arylation of Aminophenols". . p. 7347 - 7359. Retrieved 2018/07/29.