METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE

Base Information

• Chemical Name: METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE
• CAS No.: 374537-95-8
• Molecular Formula: C10H11ClO4S
• Molecular Weight: 262.714
• Hs Code.: 2916399090
• Mol file: 374537-95-8.mol

Synonyms:3-(4-Chlorosulfonylphenyl)propionicacid methyl ester;Methyl 3-(4-chlorosulfonylphenyl)propionate;Methyl4-chlorosulfonylbenzenepropanoate;

Chemical Property of METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE

Chemical Property:

• Vapor Pressure: 3.96E-05mmHg at 25°C
• Melting Point: 64-65 °C
• Refractive Index: 1.534
• Boiling Point: 352 °C at 760 mmHg
• Flash Point: 166.7 °C
• PSA: 68.82000
• Density: 1.344 g/cm³
• LogP: 2.80050
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl3-(4-(chlorosulfonyl)phenyl)propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: Xi
• Statements: 34-43
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE

There total 1 articles about METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-phenylpropanoic acid methyl ester (103-25-3) → methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate (374537-95-8)

Guidance literature:

With chlorosulfonic acid; at 40 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.12.011

Reference yield: 97.0%

methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate (374537-95-8) + 4-piperidone hydrochloride (41979-39-9) → 3-[4-(4-oxo-piperidine-1-sulfonyl)-phenyl]-propionic acid methyl ester (1020002-85-0)

Guidance literature:

With potassium carbonate; In chloroform; water; at 20 ℃;

DOI:10.1021/jm701435h

Reference yield: 90.0%

methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate (374537-95-8) → methyl 3-(4-sulfamoylphenyl)propanoate

Guidance literature:

With ammonia; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;

upstream raw materials:

3-phenylpropanoic acid methyl ester

Downstream raw materials:

methyl 3-{4-[(4-chloroanilino)sulfonyl]phenyl}propanoate

methyl 3-{4-[N-(2-iodophenyl)sulfamoyl]phenyl}propanoate

methyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl) propanoate

C₂₄H₂₀FNO₆S

Refernces

• 1、 Huang, Huang,Lu, Weiqiang,Li, Xi,Cong, Xiaoli,Ma, Hongmei,Liu, Xiaofeng,Zhang, Yu,Che, Peng,Ma, Ruoqun,Li, Honglin,Shen, Xu,Jiang, Hualiang,Huang, Jin,Zhu, Jin. "Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent". supporting information; experimental part. p. 958 - 962. Retrieved 2012/03/26.