Technology Process of 1-(Methylthio)-4-[(phenylmethyl)thio]benzene
There total 4 articles about 1-(Methylthio)-4-[(phenylmethyl)thio]benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl chloride;
With
[2,2]bipyridinyl; copper(ll) sulfate pentahydrate; sodium thiosulfate pentahydrate;
In
methanol; water;
at 80 ℃;
for 2h;
Schlenk technique;
4-methylsulfanylaniline;
With
tert.-butylnitrite;
In
methanol; water;
at 0 - 80 ℃;
for 4.66667h;
Schlenk technique;
DOI:10.1021/ol5009747
- Guidance literature:
-
benzyl chloride;
With
[2,2]bipyridinyl; copper(ll) sulfate pentahydrate; Sodium thiosulfate pentahydrate;
In
water;
at 80 ℃;
for 2h;
Schlenk technique;
C11H15N3S;
With
boron trifluoride diethyl etherate;
In
water;
at 20 ℃;
for 12h;
Schlenk technique;
DOI:10.1039/c4cc08367a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.17 h / Cooling with ice
1.2: 0.5 h / Cooling with ice
2.1: [2,2]bipyridinyl; Sodium thiosulfate pentahydrate; copper(ll) sulfate pentahydrate / water / 2 h / 80 °C / Schlenk technique
2.2: 12 h / 20 °C / Schlenk technique
With
hydrogenchloride; [2,2]bipyridinyl; copper(ll) sulfate pentahydrate; Sodium thiosulfate pentahydrate; sodium nitrite;
In
water;
DOI:10.1039/c4cc08367a
