2-bromo-5-methyl-benzene-1,4-diol

Base Information

• Chemical Name: 2-bromo-5-methyl-benzene-1,4-diol
• CAS No.: 67289-05-8
• Molecular Formula: C7H7 Br O2
• Molecular Weight: 203.035
• Hs Code.: 2908199090
• Mol file: 67289-05-8.mol

Synonyms:Hydroquinone,2-bromo-5-methyl- (6CI); NSC 338410

Chemical Property of 2-bromo-5-methyl-benzene-1,4-diol

Chemical Property:

• Vapor Pressure: 0.00123mmHg at 25°C
• Boiling Point: 289.9°Cat760mmHg
• Flash Point: 129.1°C
• PSA: 40.46000
• Density: 1.709g/cm³
• LogP: 2.16870

Purity/Quality:

99% ^*data from raw suppliers

2-BROMO-5-METHYL-1,4-BENZENEDIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-5-methyl-benzene-1,4-diol

There total 9 articles about 2-bromo-5-methyl-benzene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-Methyl-1,4-benzoquinone (553-97-9) → 2-bromo-5-methylbenzene-1,4-diol (67289-05-8)

Guidance literature:

With trimethylsilyl bromide; tetrabutylammonium tetrafluoroborate; In acetonitrile;

DOI:10.1021/ja0367602

Reference yield: 44.0%

2-bromo-5-methyl-[1,4]benzoquinone (13070-25-2) → 2-bromo-5-methylbenzene-1,4-diol (67289-05-8)

Guidance literature:

With sodium dithionite; In ethanol; water; at 50 ℃; for 1.5h; Inert atmosphere;

DOI:10.3390/md17090492

Reference yield:

2-methylbenzene-1,4-diol (95-71-6,96937-50-7) → 2-bromo-5-methylbenzene-1,4-diol (67289-05-8)

Guidance literature:

With diethyl ether; chloroform; bromine;

upstream raw materials:

2-methylbenzene-1,4-diol

2-bromo-5-methyl-[1,4]benzoquinone

2-Methyl-1,4-benzoquinone

hydrogen bromide

Downstream raw materials:

2-bromo-5-methyl-[1,4]benzoquinone

2-mercapto-5-methyl-hydroquinone

2-bromo-5-methylhydroquinone dibenzyl ether

1-bromo-2,5-dimethoxy-4-methylbenzene

Refernces

• 1、 Zheng, Haifeng,Xu, Chaoran,Wang, Yan,Kang, Tengfei,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming. "Catalytic asymmetric [2+2] cycloaddition between quinones and fulvenes and a subsequent stereoselective isomerization to 2,3-dihydrobenzofurans". supporting information. p. 6585 - 6588. Retrieved 2017/07/10.
• 2、 Evans, David A.,Wu, Jimmy. "Enantioselective rare-earth catalyzed quinone Diels-Alder reactions". . p. 10162 - 10163. Retrieved 2007/10/03.