3-CHLORO-4-METHOXYACETOPHENONE

Base Information

• Chemical Name: 3-CHLORO-4-METHOXYACETOPHENONE
• CAS No.: 37612-52-5
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 29147000
• Mol file: 37612-52-5.mol

Synonyms:4-Acetyl-2-chloroanisole;3'-Chloro-4'-methoxyacetophenone;1-(3-Chloro-4-methoxyphenyl)ethanone;Acetophenone,3'-chloro-4'-methoxy- (6CI);

Chemical Property of 3-CHLORO-4-METHOXYACETOPHENONE

Chemical Property:

• Melting Point: 74-78 °C
• Boiling Point: 295.3 °C at 760 mmHg
• Flash Point: 130 °C
• PSA: 26.30000
• Density: 1.176 g/cm³
• LogP: 2.55120
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Chloro-4-methoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-CHLORO-4-METHOXYACETOPHENONE

There total 18 articles about 3-CHLORO-4-METHOXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Chloroanisole (766-51-8) + acetyl chloride (75-36-5) → 4-acetyl-2-chloroanisole (37612-52-5)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jm970815r

Reference yield: 99.0%

methylmagnesium bromide (75-16-1) + 3-Chloro-4,N-dimethoxy-N-methyl-benzamide (173776-64-2) → 4-acetyl-2-chloroanisole (37612-52-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 3h;

DOI:10.1021/jm950664x

Reference yield: 97.0%

→ 4-acetyl-2-chloroanisole (37612-52-5)

Guidance literature:

upstream raw materials:

2-Chloroanisole

acetyl chloride

3-chloro-4-hydroxy-acetophenone

dimethyl sulfate

Downstream raw materials:

1-(3-chloro-4-methoxy-phenyl)-3t-[2]thienyl-propenone

1-(4-methoxyphenyl)ethanone

Refernces

• 1、 Rogers, David A.,Bensalah, Adam T.,Espinosa, Alvaro Tomas,Hoerr, John L.,Refai, Fares H.,Pitzel, Amy K.,Alvarado, Juan J.,Lamar, Angus A.. "Amplification of Trichloroisocyanuric Acid (TCCA) Reactivity for Chlorination of Arenes and Heteroarenes via Catalytic Organic Dye Activation". supporting information. p. 4229 - 4233. Retrieved 2019/06/17.
• 2、 Granados, Albert,Jia, Zhiyu,del Olmo, Marc,Vallribera, Adelina. "In situ Generation of Hypervalent Iodine Reagents for the Electrophilic Chlorination of Arenes". . p. 2812 - 2818. Retrieved 2019/04/08.