N-(4-chlorophenyl)-9H-fluoren-9-amine

Base Information

• Chemical Name: N-(4-chlorophenyl)-9H-fluoren-9-amine
• CAS No.: 62453-34-3
• Molecular Formula: C₁₉H₁₄ClN
• Molecular Weight: 291.78
• Mol file: 62453-34-3.mol

Synonyms:N-(4-chlorophenyl)-9H-fluoren-9-amine

Chemical Property of N-(4-chlorophenyl)-9H-fluoren-9-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(4-chlorophenyl)-9H-fluoren-9-amine

There total 8 articles about N-(4-chlorophenyl)-9H-fluoren-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N'-((2'-bromo-[1,1’-biphenyl]-2-yl)methylene)-4-methylbenzenesulfonohydrazide + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-9H-fluoren-9-amine (62453-34-3)

Guidance literature:

With copper acetylacetonate; sodium carbonate; In glycerol; at 80 ℃; for 3h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1021/cs5014877

Reference yield: 4.0%

N-<(2'-bromobiphenyl-2yl)methylene>-4-chlorobenzenamine → N-(4-chlorophenyl)-9H-fluoren-9-amine (62453-34-3) + N-(9H-fluoren-9-ylidene)-4-chlorobenzenamine (5455-00-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 7h; Heating;

DOI:10.1016/0040-4020(94)01068-B

Reference yield:

2′-bromo-[1,1′-biphenyl]-2-carbaldehyde (75295-62-4) → N-(4-chlorophenyl)-9H-fluoren-9-amine (62453-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 12 h / 80 °C

2: copper acetylacetonate; sodium carbonate / glycerol / 3 h / 80 °C / Sealed tube; Inert atmosphere; Green chemistry

With copper acetylacetonate; sodium carbonate; In ethanol; glycerol;

DOI:10.1021/cs5014877

upstream raw materials:

N-(9H-fluoren-9-ylidene)-4-chlorobenzenamine

9-fluorenone

4-chloro-aniline

2′-bromo-[1,1′-biphenyl]-2-carbaldehyde

Downstream raw materials:

N-(4-chloro-phenyl)-N-fluoren-9-yl-acetamide

Refernces

• 1、 Aziz, Jessy,Frison, Gilles,Gmez, Montserrat,Brion, Jean-Daniel,Hamze, Abdallah,Alami, Mouad. "Copper-catalyzed coupling of N -tosylhydrazones with amines: Synthesis of fluorene derivatives". supporting information. p. 4498 - 4503. Retrieved 2015/02/19.