1-BROMO-2-CHLORO-3-NITROBENZENE

Base Information

• Chemical Name: 1-BROMO-2-CHLORO-3-NITROBENZENE
• CAS No.: 3970-37-4
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236.452
• Hs Code.: 2902900000
• Mol file: 3970-37-4.mol

Synonyms:1-Bromo-2-chloro-3-nitrobenzene;

Chemical Property of 1-BROMO-2-CHLORO-3-NITROBENZENE

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 290.355 °C at 760 mmHg
• Flash Point: 129.403 °C
• PSA: 45.82000
• Density: 1.827 g/cm³
• LogP: 3.53390
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

1-Bromo-2-chloro-3-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-chloro-3-nitrobenzene is a reagent used in pharmaceutical synthesis. Used in the synthesis of benzodiazepinone bromodomain inhibitor CPI-?637 which may be applicable to cancer therapies.

Technology Process of 1-BROMO-2-CHLORO-3-NITROBENZENE

There total 12 articles about 1-BROMO-2-CHLORO-3-NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-3-nitrobezoic acid (3970-35-2) → 1-bromo-2-chloro-3-nitrobenzene (3970-37-4)

Guidance literature:

With bromine; mercury(II) oxide; In tetrachloromethane; for 3.5h; Heating; Irradiation;

DOI:10.1021/jm960401i

Reference yield: 92.0%

C6H3BrClNO5S → 1-bromo-2-chloro-3-nitrobenzene (3970-37-4)

Guidance literature:

With sulfuric acid; at 150 ℃; for 1h; Temperature;

Reference yield: 86.2%

2-bromo-6-nitroaniline (59255-95-7) → 1-bromo-2-chloro-3-nitrobenzene (3970-37-4)

Guidance literature:

With tert.-butylnitrite; copper dichloride; In acetonitrile; at 60 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-bromo-6-nitroaniline

1,2-dibromo-3-nitrobenzene

1-bromo-2-iodo-3-nitro-benzene

2-chloro-3-nitrobezoic acid

Downstream raw materials:

2-bromo-6-nitrophenyl methyl ether

3-bromo-2-chlorobenzenamine

(2-bromo-6-nitrophenyl)(3-chloropropyl)sulfane

N-(3-bromo-2-chlorophenyl)propane-1-sulfonamide

Refernces

• 1、 -. "SUBSTITUTED QUINAZOLINE COMPOUNDS AND THEIR USE AS INHIBITORS OF G12C MUTANT KRAS, HRAS AND/OR NRAS PROTEINS". Page/Page column 100. . Retrieved 2017/02/09.
• 2、 -. "INHIBITORS OF KRAS G12C". Page/Page column 271. . Retrieved 2015/04/28.