3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine

Base Information

• Chemical Name: 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine
• CAS No.: 20736-12-3
• Molecular Formula: C₃₂H₃₇NO₁₃
• Molecular Weight: 643.645
• Mol file: 20736-12-3.mol

Synonyms:3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine

Chemical Property of 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine

There total 2 articles about 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

methyl (phenyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosid)uronate (62812-42-4) + 3-O-acetylmorphine (5140-28-3) → 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine (20736-12-3) + 6-monoacetylmorphine (2784-73-8) + Diamorphine (561-27-3)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; 4 A molecular sieve; In diethyl ether; dichloromethane; at -12 ℃;

DOI:10.1055/s-2000-6413

Reference yield: 32.0%

ethyl [methyl(2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosyl)uronate] (99077-83-5) + 3-O-acetylmorphine (5140-28-3) → 3-O-acetyl-6-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucopyranosyluronate)morphine (20736-12-3) + 6-monoacetylmorphine (2784-73-8) + Diamorphine (561-27-3)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; 4 A molecular sieve; In diethyl ether; dichloromethane; at -40 ℃;

DOI:10.1055/s-2000-6413

upstream raw materials:

ethyl [methyl(2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosyl)uronate]

3-O-acetylmorphine

methyl (phenyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosid)uronate

Refernces