METHYL 5-CHLORO-2-IODOBENZOATE

Base Information

• Chemical Name: METHYL 5-CHLORO-2-IODOBENZOATE
• CAS No.: 289039-82-3
• Molecular Formula: C8H6 Cl I O2
• Molecular Weight: 296.492
• Mol file: 289039-82-3.mol

Synonyms:5-Chloro-2-iodobenzoicacid methyl ester

Chemical Property of METHYL 5-CHLORO-2-IODOBENZOATE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 295.649°C at 760 mmHg
• Flash Point: 132.604°C
• PSA: 26.30000
• Density: 1.838g/cm³
• LogP: 2.73120
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl5-Chloro-2-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-CHLORO-2-IODOBENZOATE

There total 6 articles about METHYL 5-CHLORO-2-IODOBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-chloro-2-iodo-benzoic acid (13421-00-6) + methyl iodide (74-88-4) → methyl 5-chloro-2-iodo-benzoate (289039-82-3)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 96.0%

methanol (67-56-1) + 5-chloro-2-iodo-benzoic acid (13421-00-6) → methyl 5-chloro-2-iodo-benzoate (289039-82-3)

Guidance literature:

5-chloro-2-iodo-benzoic acid; With thionyl chloride; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

methanol; at 23 ℃; for 0.5h;

Reference yield:

4-chlorobenzenesulfonyl chloride (5202-89-1) → methyl 5-chloro-2-iodo-benzoate (289039-82-3)

Guidance literature:

4-chlorobenzenesulfonyl chloride; With hydrogenchloride; In water; at 0 ℃; for 0.416667h;

With sodium nitrite; In water; at 0 ℃; for 0.166667h;

With potassium iodide; In water; at 0 - 20 ℃;

DOI:10.1246/cl.170211

upstream raw materials:

methanol

5-chloro-2-iodo-benzoic acid

4-chlorobenzenesulfonyl chloride

methyl iodide

Downstream raw materials:

methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate

tert-butyl 5-chloro-2-iodobenzoate

methyl 5-chloro-2-{(1E)-4-[2-(4-methoxybenzoyl)-4-methyl-1H-pyrrol-1-yl]-1-butenyl}benzoate

2-chlorodibenzo-1,4-thiazepin-11(10H)-one

Refernces

• 1、 Nakamura, Yu,Yoshida, Suguru,Hosoya, Takamitsu. "Facile synthesis of phthalides from methyl ortho-iodobenzoates and ketones via an iodinemagnesium exchange reaction using a silylmethyl Grignard reagent". supporting information. p. 858 - 861. Retrieved 2017/06/13.
• 2、 -. "ISOCHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS". Paragraph 0574; 0575; 0576. . Retrieved 2015/06/24.