2-Ethoxypyrimidine

Base Information

• Chemical Name: 2-Ethoxypyrimidine
• CAS No.: 3739-82-0
• Molecular Formula: C6H8 N2 O
• Molecular Weight: 124.142
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID70878915
• Nikkaji Number: J472.764I
• Mol file: 3739-82-0.mol

Synonyms:2-Ethoxypyrimidine;3739-82-0;Pyrimidine, 2-ethoxy-;ethoxypyrimidine;SCHEMBL2269826;DTXSID70878915

Chemical Property of 2-Ethoxypyrimidine

Chemical Property:

• PSA: 35.01000
• LogP: 0.87530
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 71.5

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC=CC=N1

Technology Process of 2-Ethoxypyrimidine

There total 8 articles about 2-Ethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + ethanol (64-17-5) → 2-ethoxy-pyrimidine (3739-82-0)

Guidance literature:

With NmN'''-(butane-1,4-diyl)bisguanidine; for 16h; Heating;

DOI:10.1071/ch9960573

Reference yield: 98.0%

2-cyanopyrimidine (14080-23-0) + ethanol (64-17-5) → 2-ethoxy-pyrimidine (3739-82-0)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 2h;

DOI:10.1002/ejoc.201901364

Reference yield: 82.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + sodium ethanolate (141-52-6) → 2-ethoxy-pyrimidine (3739-82-0)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 0.0111111h; microwave irradiation;

DOI:10.1016/S0040-4020(01)01182-6

upstream raw materials:

2-thioxopyrimidine

ethanol

2-chloropyrimidine

sodium ethanolate

Downstream raw materials:

Pyrimidin-2(1H)-one

Refernces

• 1、 Cao, Bao-Qian,Quan, Zheng-Jun,Ren, Ming-Zhe,Wang, Xi-Cun,Zhu, Zheng-He. "Metal- And Oxidant-Free Electrochemical Oxidative Desulfurization C-O Coupling of Thiourea-Type Compounds with Alcohols". . p. 1634 - 1642. Retrieved 2020/05/25.
• 2、 Gomez-Garcia, Omar,Salgado-Zamora, Hector,Reyes-Arellano, Alicia,Campos-Aldrete, Elena,Peralta-Cruz, Javier. "Reaction of tosylmethyl isocyanide with N-heteroaryl formamidines: An alternative approach to the synthesis of N-heteroaryl tosylimidazoles". supporting information. p. 2807 - 2810. Retrieved 2013/10/22.