TAUROURSODEOXYCHOLIC ACID SODIUM SALT

Base Information

• Chemical Name: TAUROURSODEOXYCHOLIC ACID SODIUM SALT
• CAS No.: 35807-85-3
• Molecular Formula: C26H45 N O6 S . Na
• Molecular Weight: 521.694
• Hs Code.: 2924297099
• Mol file: 35807-85-3.mol

Synonyms:Ethanesulfonicacid, 2-[[(3a,5b,7b)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, monosodiumsalt (9CI); Tauroursodeoxycholic acid, sodium salt (6CI,7CI); Sodiumtauroursodeoxycholate; Sodium tauroursodesoxycholate

Chemical Property of TAUROURSODEOXYCHOLIC ACID SODIUM SALT

Chemical Property:

• Melting Point: 173-175°C
• PSA: 135.14000
• LogP: 4.52640
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly, Heated), Ethanol (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

90%，98% ^*data from raw suppliers

Tauroursodeoxycholic acid sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tauroursodeoxycholic Acid Sodium Salt is a bile related salt for isolation of lipids and membrane-bound proteins. It is a sodium salt form of Tauroursodeoxycholic Acid which can be used in biological study of inhibition of alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption by glycyrrhizin and glycyrrhetinic acid. Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. Sodium tauroursodeoxycholate has been used in a study to assess whether ER stress is involved in palmitic acid upregulation (PA). It has also been used in a study to investigate its effect on Estradiol-17β-D-glucuronide (E-17G) induced cholestasis in female rats.

Technology Process of TAUROURSODEOXYCHOLIC ACID SODIUM SALT

There total 3 articles about TAUROURSODEOXYCHOLIC ACID SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Tau (107-35-7) + ursodeoxycholic acid (128-13-2) → tauroursodeoxycholic acid sodium salt (35807-85-3)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide; In water; acetonitrile; tert-butyl alcohol; at 20 - 80 ℃;

DOI:10.1039/c2ob25528f

Reference yield: 70.0%

sodium taurochenodeoxycholate (6009-98-9) → tauroursodeoxycholic acid sodium salt (35807-85-3)

Guidance literature:

With 7α-hydroxysteroid dehydrogenases co-immobilised on modified chitosan microspheres; NADPH; In aq. buffer; at 25 ℃; for 5h; pH=8.5; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1039/c8ra06798h

Reference yield:

sodium taurinate (7347-25-3) + C27H44O6 (196505-69-8) → tauroursodeoxycholic acid sodium salt (35807-85-3)

Guidance literature:

In water; acetone; for 0.5h;

upstream raw materials:

sodium taurinate

C₂₇H₄₄O₆

Tau

ursodeoxycholic acid

Downstream raw materials:

tauroursodeoxycholic acid

Refernces

• 1、 Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto. "Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts". experimental part. p. 4109 - 4115. Retrieved 2012/06/15.