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4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

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  • Chemical Name:4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester
  • CAS No.:1053247-83-8
  • Molecular Formula:C52H89N5O13Si
  • Molecular Weight:1020.39
  • Hs Code.:
  • Mol file:1053247-83-8.mol
4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-<i>tert</i>-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Synonyms:4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Suppliers and Price of 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester
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Chemical Property of 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester Edit
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Technology Process of 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

There total 18 articles about 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 11 steps
1: 95 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
2: 83 percent / tetrahydrofuran / -78 °C
3: 77 percent / potassium borohydride / methanol / -30 - 0 °C
4: 82 percent / 2,6-lutidine / CH2Cl2 / 20 °C
5: 81 percent / aq. NaOH / tetrahydrofuran; methanol / 0 - 20 °C
6: 60 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
7: 100 percent / Pd(PPh3)4; morpholine / tetrahydrofuran / 20 °C
8: Pyr / CH2Cl2
9: 79 percent / DIEA; DMAP / CH2Cl2 / 0 - 20 °C
10: MgBr2*Et2O / CH2Cl2 / -15 - 0 °C
11: H2 / Pd/C / ethyl acetate; methanol / 20 °C
With morpholine; pyridine; 2,6-dimethylpyridine; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); potassium borohydride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja010222c
Guidance literature:
Multi-step reaction with 4 steps
1: 98 percent / H2 / Pd/C / methanol; ethyl acetate / 5 h
2: 79 percent / DIEA; DMAP / CH2Cl2 / 0 - 20 °C
3: MgBr2*Et2O / CH2Cl2 / -15 - 0 °C
4: H2 / Pd/C / ethyl acetate; methanol / 20 °C
With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja010222c
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