2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHYLAMINE HYDROCHLORIDE
• CAS No.: 261633-71-0
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Hs Code.: 2932999099
• Mol file: 261633-71-0.mol

Synonyms:5-(Aminomethyl)-2,3-dihydro-1,4-benzodioxine;[(2,3-Dihydrobenzo[1,4]dioxin-5-yl)methyl]amine;(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanamine;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)methanamine;

Chemical Property of 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00247mmHg at 25°C
• Boiling Point: 287.5 °C at 760 mmHg
• Flash Point: 138.8 °C
• PSA: 44.48000
• Density: 1.194 g/cm³
• LogP: 2.41880

Purity/Quality:

98%min ^*data from raw suppliers

5-(Aminomethyl)-1,4-benzodioxane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: C:Corrosive
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dihydro-1,4-benzodioxin-5-ylmethylamine, HCl

Technology Process of 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHYLAMINE HYDROCHLORIDE

There total 5 articles about 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,3-dihydro-benzo[1,4]dioxin-5-ylmethyl)-isoindole-1,3-dione (214894-98-1) → 2,3-dihydro-1,4-benzodioxin-5-methanamine (261633-71-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1016/S0968-0896(99)00265-5

Reference yield:

5-methyl-2,3-dihydrobenzo[b][1,4]dioxine (33632-34-7) → 2,3-dihydro-1,4-benzodioxin-5-methanamine (261633-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / Heating

2: potassium iodide / dimethylformamide / 3 h / Heating

3: hydrazine hydrate / ethanol / 5 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrazine hydrate; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; 1: Bromination / 2: Alkylation / 3: hydrazinolysis;

DOI:10.1016/S0968-0896(99)00265-5

Reference yield:

3-methylbenzene-1,2-diol (488-17-5) → 2,3-dihydro-1,4-benzodioxin-5-methanamine (261633-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / Heating

2: N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / Heating

3: potassium iodide / dimethylformamide / 3 h / Heating

4: hydrazine hydrate / ethanol / 5 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; hydrazine hydrate; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetone; 1: Cyclization / 2: Bromination / 3: Alkylation / 4: hydrazinolysis;

DOI:10.1016/S0968-0896(99)00265-5

upstream raw materials:

2-(2,3-dihydro-benzo[1,4]dioxin-5-ylmethyl)-isoindole-1,3-dione

5-methyl-2,3-dihydrobenzo[b][1,4]dioxine

3-methylbenzene-1,2-diol

5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine

Downstream raw materials:

tert-butyl 2-((tert-butoxycarbonyl)(methyl)amino)ethyl(3-(5-((2,3-dihydrobenzo[b][1,4]dioxin-5-yl-methyl)carbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzyl)carbamate

Refernces

• 1、 Charton, Isabelle,Mamai, Ahmed,Bennejean, Caroline,Renard, Pierre,Howell, Edward H.,Guardiola-Lemaitre, B.Eatrice,Delagrange, Philippe,Morgan, Peter J.,Viaud, Marie-Claude,Guillaumet, G.Erald. "Substituted oxygenated heterocycles and thio-analogues: Synthesis and biological evaluation as melatonin ligands". . p. 105 - 114. Retrieved 2007/10/03.