Tedatioxetine phosphate

Base Information

• Chemical Name: Tedatioxetine phosphate
• CAS No.: 960151-84-2
• Molecular Formula: C₁₈H₂₁NS*H₃O₄P
• Molecular Weight: 381.433
• Mol file: 960151-84-2.mol

Synonyms:Tedatioxetine phosphate

Chemical Property of Tedatioxetine phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tedatioxetine phosphate

There total 8 articles about Tedatioxetine phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(4-methylphenylsulfanyl)phenyl]piperidine (508233-95-2) → Tedatioxetine phosphate (960151-84-2)

Guidance literature:

With phosphoric acid; In ethanol; ethyl acetate;

Reference yield:

para-thiocresol (106-45-6) → Tedatioxetine phosphate (960151-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere

2.1: n-butyllithium / n-heptane; hexane / 1.17 h / 20 °C / Inert atmosphere

2.2: -40 °C

3.1: hydrogen bromide; acetic acid / 18 h / 80 °C

4.1: sodium hydroxide / ethyl acetate / 0.25 h / pH 13 - 14

5.1: phosphoric acid / ethyl acetate; ethanol

With n-butyllithium; phosphoric acid; potassium tert-butylate; hydrogen bromide; acetic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; hexane; n-heptane; ethyl acetate;

Reference yield:

2,3-dibromobenzene (583-53-9) → Tedatioxetine phosphate (960151-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere

2.1: n-butyllithium / n-heptane; hexane / 1.17 h / 20 °C / Inert atmosphere

2.2: -40 °C

3.1: hydrogen bromide; acetic acid / 18 h / 80 °C

4.1: sodium hydroxide / ethyl acetate / 0.25 h / pH 13 - 14

5.1: phosphoric acid / ethyl acetate; ethanol

With n-butyllithium; phosphoric acid; potassium tert-butylate; hydrogen bromide; acetic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; hexane; n-heptane; ethyl acetate;

upstream raw materials:

4-[2-(4-methylphenylsulfanyl)phenyl]piperidine

1-bromo-2-(4-methylphenylsulfanyl)benzene

para-thiocresol

2,3-dibromobenzene

Refernces

• 1、 -. "4- [2- (4-METHYLPHENYLSULFANYL) PHENYL] PIPERIDINE FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME (IBS)". Page/Page column 6. . Retrieved 2010/06/16.
• 2、 -. "CRYSTALLINE FORMS OF 4- [2- (4-METHYLPHENYLSULFANYL) -PHENYL] PIPERIDINE WITH COMBINED SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITION FOR THE TREATMENT OF NEUROPATHIC PAIN". Page/Page column 23; 24. . Retrieved 2008/06/13.