4-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE
• CAS No.: 255051-14-0
• Molecular Formula: C12H15ClF3N
• Molecular Weight: 265.706
• Hs Code.: 2933399090
• Mol file: 255051-14-0.mol

Synonyms:Piperidine,4-[2-(trifluoromethyl)phenyl]-, hydrochloride (9CI);4-(2-Trifluoromethylphenyl)piperidinehydrochloride;

Chemical Property of 4-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000626mmHg at 25°C
• Boiling Point: 305.1 °C at 760 mmHg
• Flash Point: 138.3 °C
• PSA: 12.03000
• LogP: 4.30320
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-[2-(Trifluoromethyl)phenyl]piperidinehydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

There total 8 articles about 4-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-(trifluoromethyl)phenyl)piperidine (308823-90-7) → 4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride (255051-14-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 20 ℃; for 0.166667h;

Reference yield: 60.0%

C19H18F3N*ClH (1370256-36-2) → 4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride (255051-14-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;

DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

→ 4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride (255051-14-0) + piperidine hydrochloride (6091-44-7)

Guidance literature:

upstream raw materials:

1-benzyl-4-(2-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

1-phenylmethyl-4-piperidone

1-benzyl-4-hydroxy-4-(2-tri-fluoromethylphenyl)piperidine

C₁₉H₁₈F₃N*ClH

Refernces

• 1、 Cioffi, Christopher L.,Racz, Boglarka,Freeman, Emily E.,Conlon, Michael P.,Chen, Ping,Stafford, Douglas G.,Schwarz, Daniel M.C.,Zhu, Lei,Kitchen, Douglas B.,Barnes, Keith D.,Dobri, Nicoleta,Michelotti, Enrique,Cywin, Charles L.,Martin, William H.,Pearson, Paul G.,Johnson, Graham,Petrukhin, Konstantin. "Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease". . p. 5863 - 5888. Retrieved 2015/08/24.
• 2、 Cioffi, Christopher L.,Dobri, Nicoleta,Freeman, Emily E.,Conlon, Michael P.,Chen, Ping,Stafford, Douglas G.,Schwarz, Daniel M. C.,Golden, Kathy C.,Zhu, Lei,Kitchen, Douglas B.,Barnes, Keith D.,Racz, Boglarka,Qin, Qiong,Michelotti, Enrique,Cywin, Charles L.,Martin, William H.,Pearson, Paul G.,Johnson, Graham,Petrukhin, Konstantin. "Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and stargardt disease". . p. 7731 - 7757. Retrieved 2015/01/09.