8-Quinolinol, 7-fluoro-

Base Information

• Chemical Name: 8-Quinolinol, 7-fluoro-
• CAS No.: 35048-10-3
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.1484
• Hs Code.: 2933491090
• Mol file: 35048-10-3.mol

Synonyms:7-Fluoro-8-quinolinol;

Chemical Property of 8-Quinolinol, 7-fluoro-

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 296.205 °C at 760 mmHg
• PKA: 2.04±0.50(Predicted)
• Flash Point: 132.94 °C
• Density: 1.366 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

7-Fluoroquinolin-8-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinolinol, 7-fluoro-

There total 4 articles about 8-Quinolinol, 7-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-amino-6-fluoro phenol (53981-25-2) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 7-fluoro-8-hydroxyquinoline (35048-10-3)

Guidance literature:

With sulfuric acid; In nitrobenzene; at 140 ℃; for 2h; Sealed tube;

Reference yield: 43.0%

acrylaldehyde diethyl acetal (3054-95-3) + 2-amino-6-fluoro phenol (53981-25-2) → 7-fluoro-8-hydroxyquinoline (35048-10-3)

Guidance literature:

With hydrogenchloride; In water; at 111 ℃; for 24h;

DOI:10.1016/j.tetlet.2015.09.145

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 7-fluoro-8-hydroxyquinoline (35048-10-3)

Guidance literature:

With sulfuric acid; for 6h; Heating;

DOI:10.1039/b516757d

upstream raw materials:

2-fluoro-6-nitrophenol

glycerol

2-amino-6-fluoro phenol

acrylaldehyde diethyl acetal

Refernces

• 1、 Buchler, Ingrid,Akuma, Daniel,Au, Vinh,Carr, Gregory,De León, Pablo,Depasquale, Michael,Ernst, Glen,Huang, Yifang,Kimos, Martha,Kolobova, Anna,Poslusney, Michael,Wei, Huijun,Swinnen, Dominique,Montel, Florian,Moureau, Florence,Jigorel, Emilie,Schulze, Monika-Sarah E. D.,Wood, Martyn,Barrow, James C.. "Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase". . p. 9647 - 9665. Retrieved 2018/11/23.
• 2、 Ramann, Ginelle A.,Cowen, Bryan J.. "Quinoline synthesis by improved Skraup-Doebner-Von Miller reactions utilizing acrolein diethyl acetal". supporting information. p. 6436 - 6439. Retrieved 2015/11/16.