Difluoromethyl 2,2,3,3-tetrafluoropropyl ether

Base Information

• Chemical Name: Difluoromethyl 2,2,3,3-tetrafluoropropyl ether
• CAS No.: 35042-99-0
• Molecular Formula: C4H4 F6 O
• Molecular Weight: 182.066
• Hs Code.: 2909199090
• European Community (EC) Number: 808-024-0
• DSSTox Substance ID: DTXSID60371783
• Nikkaji Number: J1.254.504E
• Wikidata: Q66084512
• Mol file: 35042-99-0.mol

Synonyms:35042-99-0;Difluoromethyl 2,2,3,3-tetrafluoropropyl ether;2,2,3,3-Tetrafluoropropyl difluoromethyl ether;3-(difluoromethoxy)-1,1,2,2-tetrafluoropropane;Propane, 3-(difluoromethoxy)-1,1,2,2-tetrafluoro-;2,2,3,3-TETRAFLUOROPROPYLDIFLUOROMETHYLETHER;1,1,2,2-tetrafluoro-3-(difluoromethoxy)-propane;HFE-356pcf;HFE-356pcf3;SCHEMBL186811;DTXSID60371783;PCTQNZRJAGLDPD-UHFFFAOYSA-N;MFCD00236119;AKOS006229196;AS-83794;D4472;FT-0624926;T70808

Chemical Property of Difluoromethyl 2,2,3,3-tetrafluoropropyl ether

Chemical Property:

• Vapor Pressure: 194mmHg at 25°C
• Refractive Index: 1.299
• Boiling Point: 62°Cat760mmHg
• Flash Point: °C
• PSA: 9.23000
• Density: 1.354g/cm³
• LogP: 2.12600
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 182.01663372
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

98%,99%, ^*data from raw suppliers

Difluoromethyl 2,2,3,3-Tetrafluoropropyl Ether ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(F)F)(F)F)OC(F)F
• Uses: Difluoromethyl 2,2,3,3-Tetrafluoropropyl Ether is a a component of refrigerant fluids.

Technology Process of Difluoromethyl 2,2,3,3-tetrafluoropropyl ether

There total 3 articles about Difluoromethyl 2,2,3,3-tetrafluoropropyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Chlorodifluoromethane (75-45-6) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 2,2,3,3-tetrafluoropropyl difluoromethyl ether (35042-99-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 1h;

DOI:10.1016/j.jfluchem.2005.12.034

Reference yield: 50.0%

2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2-difluoro-2-(fluorosulfonyl)acetic acid (1717-59-5) → trifluoromethan (75-46-7) + 2,2,3,3-tetrafluoropropyl difluoromethyl ether (35042-99-0)

Guidance literature:

sodium sulfate; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1016/S0022-1139(00)82808-0

Reference yield:

→ 2,2,3,3-tetrafluoropropyl difluoromethyl ether (35042-99-0)

Guidance literature:

2,2,3,3-Tetrafluorpropan-1-ol, KOH/CHClF2;

DOI:10.1016/S0022-1139(00)81010-6

upstream raw materials:

2,2,3,3-tetrafluoropropanol

2,2-difluoro-2-(fluorosulfonyl)acetic acid

Chlorodifluoromethane

Refernces

• 1、 Chen, Qing-Yun,Wu, Sheng-Wen. "A SIMPLE CONVENIENT METHOD FOR PREPARATION OF DIFLUOROMETHYL ETHERS USING FLUOROSULFONYLDIFLUOROACETIC ACID AS A DIFLUOROCARBENE PRECURSOR". . p. 433 - 440. Retrieved 2007/10/02.