ethyl 5-(chloromethyl)-3-isoxazolecarboxylate

Base Information

• Chemical Name: ethyl 5-(chloromethyl)-3-isoxazolecarboxylate
• CAS No.: 3209-40-3
• Molecular Formula: C7H8 Cl N O3
• Molecular Weight: 189.598
• Hs Code.: 2934999090
• Mol file: 3209-40-3.mol

Synonyms:Ethyl5-(chloromethyl)isoxazole-3-carboxylate

Chemical Property of ethyl 5-(chloromethyl)-3-isoxazolecarboxylate

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 312.398°C at 760 mmHg
• PKA: -5.98±0.50(Predicted)
• Flash Point: 142.733°C
• PSA: 52.33000
• Density: 1.285g/cm³
• LogP: 1.59010

Purity/Quality:

98%min ^*data from raw suppliers

ethyl5-(chloromethyl)isoxazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-(chloromethyl)-3-isoxazolecarboxylate

There total 1 articles about ethyl 5-(chloromethyl)-3-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propynyl chloride (624-65-7) + ethyl 2-chloro-2-(hydroxyimino)acetate (14337-43-0) → 5-chloromethyl-isoxazole-3-carboxylic acid ethyl ester (3209-40-3)

Guidance literature:

With triethylamine; at 10 - 20 ℃;

Reference yield: 100.0%

5-chloromethyl-isoxazole-3-carboxylic acid ethyl ester (3209-40-3) + benzyl-methyl-amine (103-67-3) → ethyl 5-{[benzyl(methyl)amino]methyl}isoxazole-3-carboxylate (1211571-32-2)

Guidance literature:

sodium iodide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 77.0%

5-chloromethyl-isoxazole-3-carboxylic acid ethyl ester (3209-40-3) → 5-chloromethylisoxazole-3-carboxylic acid (3209-41-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 60 - 70 ℃; for 6h;

upstream raw materials:

2-propynyl chloride

ethyl 2-chloro-2-(hydroxyimino)acetate

Downstream raw materials:

5-Chloromethyl-isoxazole-3-carboxylic acid (2,6-dimethyl-phenyl)-amide

5-chloromethylisoxazole-3-carboxylic acid

ethyl 5-{[benzyl(methyl)amino]methyl}isoxazole-3-carboxylate

ethyl 5-{[(3-phenylpropyl)amino]methyl}isoxazole-3-carboxylate

Refernces