SMZ chloride

Base Information

• Chemical Name: SMZ chloride
• CAS No.: 1057714-26-7
• Molecular Formula: C₁₀H₁₁N₃O₃S*ClH
• Molecular Weight: 289.743
• Mol file: 1057714-26-7.mol

Synonyms:SMZ chloride

Chemical Property of SMZ chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of SMZ chloride

There total 2 articles about SMZ chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

N-acetylsulfamethoxazole (21312-10-7) → SMZ chloride (1057714-26-7)

Guidance literature:

With thionyl chloride; In methanol; for 2h; Reflux;

DOI:10.1007/s11164-011-0327-6

Reference yield:

sulfamethoxazole (723-46-6) → SMZ chloride (1057714-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 11 h / 0 - 30 °C

2: thionyl chloride / methanol / 2 h / Reflux

With thionyl chloride; potassium carbonate; In methanol; acetone;

DOI:10.1007/s11164-011-0327-6

Reference yield: 57.0%

SMZ chloride (1057714-26-7) + methyl 2-[(tert-butoxycarbonyl)amino]acrylate (55477-80-0) → methyl 2-((tert-butoxycarbonyl)amino)-2-hydroxy-3-(4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)propanoate

Guidance literature:

SMZ chloride; With sodium nitrite; In water; acetone; for 0.25h;

methyl 2-[(tert-butoxycarbonyl)amino]acrylate; In water; acetone; at 0 ℃; for 0.333333h;

With ferrocene; In water; acetone; at 0 ℃; for 1h;

DOI:10.1002/chem.201804094

upstream raw materials:

sulfamethoxazole

N-acetylsulfamethoxazole

Refernces