2-(Methoxymethyl)pyrimidin-4-amine

Base Information

• Chemical Name: 2-(Methoxymethyl)pyrimidin-4-amine
• CAS No.: 3122-85-8
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.157
• Hs Code.: 2933599090
• European Community (EC) Number: 872-400-0
• DSSTox Substance ID: DTXSID10695966
• Wikidata: Q82625361
• Mol file: 3122-85-8.mol

Synonyms:2-(Methoxymethyl)pyrimidin-4-amine;3122-85-8;4-Amino-2-(methoxymethyl)pyrimidine;2-METHOXYMETHYL-PYRIMIDIN-4-YLAMINE;MFCD11043789;SCHEMBL1014696;DTXSID10695966;AKOS005266554;CS-W003752;SB36524;CS-11467;SY021957;EN300-302318;A876001;Z960787432

Chemical Property of 2-(Methoxymethyl)pyrimidin-4-amine

Chemical Property:

• Melting Point: 111-112 °C
• Boiling Point: 247.2±20.0 °C(Predicted)
• PKA: 4.75±0.10(Predicted)
• PSA: 61.76000
• Density: 1.185±0.06 g/cm3(Predicted)
• LogP: 0.13530
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 139.074561919
• Heavy Atom Count: 10
• Complexity: 99

Purity/Quality:

98%min ^*data from raw suppliers

2-(methoxymethyl)pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=NC=CC(=N1)N

Technology Process of 2-(Methoxymethyl)pyrimidin-4-amine

There total 2 articles about 2-(Methoxymethyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chloro-2-(methoxymethyl)pyrimidine (105950-89-8) → 4-amino-2-(methoxymethyl)pyrimidine (3122-85-8)

Guidance literature:

With ammonium hydroxide; at 120 ℃; for 15h; sealed tube;

DOI:10.3987/COM-07-11302

Reference yield:

→ 4-amino-2-(methoxymethyl)pyrimidine (3122-85-8)

Guidance literature:

upstream raw materials:

4-chloro-2-(methoxymethyl)pyrimidine

Refernces

• 1、 -. "11B-HSD1 inhibitors for the treatment of diabetes". Page/Page column 12. . Retrieved 2008/06/13.