2-Methoxyethanimidamide

Base Information

• Chemical Name: 2-Methoxyethanimidamide
• CAS No.: 3122-73-4
• Molecular Formula: C3H8 N2 O
• Molecular Weight: 88.1093
• Hs Code.: 2925290090
• DSSTox Substance ID: DTXSID90402372
• Nikkaji Number: J1.766.266J
• Wikidata: Q82205773
• Mol file: 3122-73-4.mol

Synonyms:2-methoxyethanimidamide;3122-73-4;2-Methoxy-Acetamidine;2-Methoxyacetimidamide;Ethanimidamide, 2-methoxy-;2-methoxyacetamidine;DTXSID90402372;XMSFMNAYWPDMBJ-UHFFFAOYSA-N;MFCD05663316;AKOS000185335;SB36522;D87837;EN300-1858394;A912265

Chemical Property of 2-Methoxyethanimidamide

Chemical Property:

• Boiling Point: 127.5±42.0 °C(Predicted)
• PKA: 10.56±0.40(Predicted)
• PSA: 59.10000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 0.36880
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 88.063662883
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99%min ^*data from raw suppliers

2-Methoxyethanimidamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=N)N

Technology Process of 2-Methoxyethanimidamide

There total 5 articles about 2-Methoxyethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-methoxyacetonitrile (1738-36-9) + ammonium chloride (12125-02-9) → 2-methoxyacetamidine (3122-73-4)

Guidance literature:

ammonium chloride; With trimethylaluminum; In toluene; at 0 - 20 ℃; for 1.5h;

2-methoxyacetonitrile; In toluene; at 80 ℃; for 18h;

Reference yield: 88.0%

2-methoxyacetonitrile (1738-36-9) → 2-methoxyacetamidine (3122-73-4)

Guidance literature:

2-methoxyacetonitrile; With sodium methylate; In methanol; at 20 ℃; for 48h;

With ammonium chloride; In methanol; for 12h;

Reference yield:

ethyl 2-methoxyacetimidate monohydrochloride (42945-65-3) → 2-methoxyacetamidine (3122-73-4)

Guidance literature:

With ammonia; In ethanol; at 25 ℃; for 72h; Yield given;

DOI:10.1016/0968-0896(96)00148-4

upstream raw materials:

2-methoxyacetimidate d'ethyle

ethyl 2-methoxyacetimidate monohydrochloride

2-methoxyacetonitrile

ammonium chloride

Downstream raw materials:

2-(methoxymethyl)pyrimidine-4,6-diol

5-bromo-2-methoxymethyl-pyrimidine-4-carboxylic acid

5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-2-methoxymethyl-6-methyl-pyrimidine

5,5-bis(4-fluorophenyl)-2-(methoxymethyl)-3,5-dihydro-4H-imidazol-4-one

Refernces

• 1、 -. "NITROGEN-CONTAINING HETEROARYL DERIVATIVES". Page/Page column 46-47. . Retrieved 2011/08/08.
• 2、 Moore, William M.,Webber, R. Keith,Fok, Kam F.,Jerome, Gina M.,Kornmeier, Christine M.,Tjoeng, Foe S.,Currie, Mark G.. "Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element". . p. 1559 - 1564. Retrieved 2007/10/03.